Simple and efficient microwave-assisted synthesis of new N-biphenyl cinnamamides/3-arylpropanamides and C6-substituted phenanthridines

We hereby report an efficient method for the preparation of a series of new N-biphenyl-cinnamamides/3-arylpropanamides through a three-step, clean, good-yielding, environment-friendly microwave-assisted procedure for the Suzuki-Miyaura coupling/basic hydrolysis/N-amidation from 2-bromoacetanilides and arylboronic acids as available starting reagents. The N-biphenyl-3-arylpropanamides obtained were con-verted into new 6-phenethylphenanthridine derivatives carrying out a subsequent cyclization reaction by means of a Pictet-Hubert microwave-assisted process. The structures of the compounds were fully char-acterized by FT-IR, 1H, and 13C NMR and are reported for the first time. (c) 2023 Elsevier Ltd. All rights reserved.

Automated summary

We report an efficient method for synthesizing a series of new N-biphenyl-cinnamamides/3-arylpropanamides through a three-step, clean, good-yielding, and environmentally-friendly microwave-assisted procedure. The compounds were fully characterized by FT-IR, 1H, and 13C NMR and are reported for the first time.