Journal
TETRAHEDRON LETTERS
Volume 121, Issue -, Pages -Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2023.154473
Keywords
Annulation; Copper; One -pot; Pyridazinones
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A three-component synthesis of pyridazinones using Cu(OTf)2 as catalyst has been developed, which shows high tolerance towards various functional groups including aliphatic, aromatic and hetero-aromatic aldehydes, and gives moderate to high yields of 2,6-diaryl-4,5-dihydropyridazin-3(2H)-one products.
The three-component synthesis of pyridazinones from aldehydes, arylhydrazines and 3-acryloyloxazo-lidin-2-one catalyzed by Cu(OTf)2 has been developed. This strategy exhibits high tolerance towards many functional groups including various aliphatic, aromatic and hetero-aromatic aldehydes to give 2,6-diaryl-4,5-dihydropyridazin-3(2H)-one products in moderate to high yields.(c) 2023 Elsevier Ltd. All rights reserved.
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