New azaspirene derivatives from marine-derived fungus Aspergillus micronesiensis NF666

Azaspirene derivatives are widespread natural products in fungi. Here we reported five new azaspirenes A-E (1-5) from the marine mud-derived endophytic fungus Aspergillus micronesiensis NF666. Their structures were unambiguously determined by an extensive analysis of HRESIMS and NMR data. All compounds were evaluated on antimicrobial activities against five pathogens by the agar diffusion method. Moreover, a plausible biosynthetic pathway of azaspirenes A (1) is proposed in this work. & COPY; 2023 Elsevier Ltd. All rights reserved.

Automated summary

Five new Azaspirenes A-E were discovered in the marine mud-derived endophytic fungus Aspergillus micronesiensis NF666. Their structures were determined through extensive analysis of HRESIMS and NMR data. The antimicrobial activities of these compounds against five pathogens were evaluated using the agar diffusion method. Furthermore, a plausible biosynthetic pathway of Azaspirenes A (1) was proposed in this study.