Mucosal vs. cutaneous advancement flaps for the treatment of chronic anal fissures: a randomized clinical trial

Purpose The aim of this study was to compare two surgical treatment methods for chronic anal fissures (CAF), mucosal advancement flap anoplasty (MAFA) and cutaneous advancement flap anoplasty (CAFA). Methods A randomized, blinded clinical trial was conducted on patients with CAF refractory to medical treatment referred to a tertiary-level hospital between January 2021 and December 2022. The patients were assigned to two groups by block randomization and were compared in terms of outcome, pain reduction, and complications. Results There were 30 patients (male to female ratio 2:3, median age 42 years [range 25-59 years]). Both techniques reduced anal pain significantly (p = 0.001); however, there were no significant differences between MAFA and CAFA groups in recurrence, duration of healing, postoperative pain, and postoperative bleeding. No patient suffered from fecal incontinence (Wexner score = 0) or flap necrosis postoperatively. Only two patients in the MAFA group (1 and 3 months after surgery) and one patient in the CAFA group (2 months after surgery) had recurrence (total recurrence rate = 10%, healing rate = 90%). All of the patients were satisfied with their surgical results. Conclusion Mucosal and cutaneous anal advancement flap techniques are effective and comparable surgical procedures for the treatment of chronic anal fissures with minimal complications, fast healing process, and minimal postoperative pain and complications.

Automated summary

This study compared two surgical methods for treating chronic anal fissures, mucosal advancement flap anoplasty (MAFA) and cutaneous advancement flap anoplasty (CAFA). A randomized clinical trial was conducted involving patients with refractory fissures, and outcomes, pain reduction, and complications were compared. Both techniques significantly reduced anal pain, and there were no significant differences in recurrence, healing duration, postoperative pain, and bleeding between the two groups. Overall, the surgical procedures were effective with minimal complications and satisfactory results.