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SYNTHESIS-STUTTGART
Volume -, Issue -, Pages -Publisher
GEORG THIEME VERLAG KG
DOI: 10.1055/a-2116-5517
Keywords
l -Proline; organocatalytic reaction; spirooxindole; aza-Michael- addition; aldol condensation
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An efficient and diastereoselective synthesis of 1',4'-dihydro-2'H-spiro[indoline-3,3'-quinolin]-2-one derivatives was achieved using a catalytic amount of L-proline. The tandem reaction involved aza-Michael addition and aldol reaction, and proceeded under mild conditions with a broad substrate scope and excellent diastereoselectivity, providing good to excellent yields.
An efficient diastereoselective synthesis of 1',4'-dihydro-2'H-spiro[indoline-3,3'-quinolin]-2-one derivatives was achieved using catalytic amount of L-proline. The key reactions involved in the present tandem reaction are aza-Michael addition and aldol reaction. This atom economic reaction proceeded under mild conditions with a broad substrate scope and excellent diastereoselectivity in good to excellent yields.
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