Direct a-Trifluoromethylthiolation of Carboxylic Acids Enabled by Boron Catalysis

Summary: In this work, C-H functionalization of silyl ethers via carbene-induced C-H insertion has been achieved, providing an efficient synthetic disconnection strategy. The use of different catalyst preferences has enabled site- and stereoselective functionalization at different positions relative to the siloxy group. Additionally, a machine learning model has been developed to predict the major product, aiding in the application of these methods to new substrates.