Journal
SYNLETT
Volume -, Issue -, Pages -Publisher
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0041-1738437
Keywords
Umpolung; masked acyl cyanides; nitroalkenes; Michael addition reaction; malononitriles; asymmetric catalysis
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A highly efficient method has been developed for the synthesis of (2-nitro-1-phenylethyl)malononitriles through a Michael addition reaction. The reaction takes place with excellent yields (90-98%) under mild conditions, providing a scalable approach to a series of the title compounds. An asymmetric version of the reaction has also been briefly explored.
A highly efficient method has been developed for the synthesis of (2-nitro-1-phenylethyl)malononitriles through a Michael addition reaction between substituted nitroolefins and masked acyl cyanide reagents, serving as carbon monoxide equivalents. Under mild conditions, the reaction took place with excellent yields (90-98%), providing a short entry into a series of the title compounds in a scalable fashion. An asymmetric version of this reaction has also been briefly explored.
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