No role for electroencephalogram in the initial work-up of pediatric acute lymphoblastic leukemia

Article Clinical Neurology

Clinical Analysis of Childhood Acute Lymphoblastic Leukemia With Epilepsy Seizures

Rui Li et al.

Summary: The clinical characteristics of epileptic seizures in children with acute lymphoblastic leukemia (ALL) during treatment were analyzed. Epileptic seizures mainly occurred in the induction remission period, maintenance treatment period, and after bone marrow transplantation. The common causes were MTX-related demyelinating encephalopathy and reversible posterior encephalopathy syndrome (PRES). Convulsion was the first symptom. Early neuroimaging and EEG examination are important for early diagnosis and treatment.

FRONTIERS IN NEUROLOGY (2022)

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Article Oncology

Acute neurological complications during acute lymphoblastic leukemia therapy: A single-center experience over 10 years

Emine A. Rahiman et al.

Summary: This analysis evaluated the profile of acute neuro-toxicity in children with ALL, revealing that 10% of patients experienced acute neurological events, mainly seizures and neurological deficits. The study highlighted the high morbidity and incidence of neuroinfections as major concerns in this patient population.

INDIAN JOURNAL OF CANCER (2021)

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Article Clinical Neurology