☆ 4.7 Article

Allosteric modulation of ryanodine receptor RyR1 by nucleotide derivatives

STRUCTURE (2023)

Related references

Note: Only part of the references are listed.

Article Cardiac & Cardiovascular Systems

A junctional cAMP compartment regulates rapid Ca2+ signaling in atrial myocytes

Soren Brandenburg et al.

Summary: This study found constitutively elevated levels of cAMP at the axial tubule junctional compartments in atrial myocytes, sustained by increased adenylyl cyclase activity. This compartmentalized cAMP level drove the phosphorylation of RyR2 clusters and increased L-type Ca2+ current density at the junctional sites. Beta-adrenergic stimulation overcame the compartmentation of cAMP by activating non-junctional RyR2 clusters throughout the cell.

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2022)

Add to Collection

Article Cardiac & Cardiovascular Systems

Preserved cardiac performance and adrenergic response in a rabbit model with decreased ryanodine receptor 2 expression

Jingjing Zheng et al.

Summary: RyR2 is a crucial protein in the heart that regulates the release of Ca2+. This study found that a decrease in RyR2 expression has limited impact on overall cardiac function, highlighting the redundancy of RyR2 protein expression and the plasticity of the excitation-contraction coupling apparatus.

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2022)

Add to Collection

Review Physiology

CALCIUM-RELEASE CHANNELS: STRUCTURE AND FUNCTION OF IP3 RECEPTORS AND RYANODINE RECEPTORS

Kellie A. Woll et al.

Summary: Ca2+-release channels are membrane proteins that control the release of Ca2+ from the endoplasmic and sarcoplasmic reticulum. They are activated by cytosolic Ca2+ and have a common architecture, with additional modules in the cytosolic region for ryanodine receptors (RyRs). Their regulation involves the binding of proteins and small molecules, with major triggers including IP3 and membrane depolarization. Electron microscopic studies have provided valuable insights into their structure and mechanisms, including the binding of auxiliary proteins, regulation of channel opening, and disease-associated mutations.

PHYSIOLOGICAL REVIEWS (2022)

Add to Collection

Article Biochemistry & Molecular Biology

High-resolution structure of the membrane-embedded skeletal muscle ryanodine receptor

Zephan Melville et al.

Summary: This study used cryo-EM to investigate the high-resolution structure of the RyR channel on the sarcoplasmic reticulum. The findings offer validation for detergent-based structures of the RyR and provide a starting point for simulating the chemical gradient in the sarcoplasmic reticulum.

STRUCTURE (2022)

Add to Collection

Article Biochemistry & Molecular Biology

A drug and ATP binding site in type 1 ryanodine receptor

Zephan Melville et al.

Summary: The ryanodine receptor is crucial for excitation-contraction coupling in skeletal and cardiac muscle, and Rycals can prevent SR Ca2+ leak caused by mutations and post-translational modifications. Through cryogenic-electron microscopy, a model of RyR1 with a high resolution was presented, showing the binding site and mechanism of action of Rycal ARM210 in stabilizing the closed state of RyR1.

STRUCTURE (2022)

Add to Collection

Article Multidisciplinary Sciences

Structural basis for activation and gating of IP3 receptors

Emily A. Schmitz et al.

Summary: This study presents cryo-EM structures of human type-3 IP3 receptors, revealing the molecular mechanism of receptor activation. The structures demonstrate how IP3-induced conformational changes prime the receptor for activation by Ca2+, and how ATP modulates the activity.

NATURE COMMUNICATIONS (2022)

Add to Collection

Article Biology

Ca2+ inactivation of the mammalian ryanodine receptor type 1 in a lipidic environment revealed by cryo-EM

Ashok R. Nayak et al.

Summary: Activation and inactivation of intracellular Ca2+ channel are regulated by the binding of Ca2+ and the conformational changes of the receptor.

ELIFE (2022)

Add to Collection

Article Multidisciplinary Sciences

Structural analyses of human ryanodine receptor type 2 channels reveal the mechanisms for sudden cardiac death and treatment

Marco C. Miotto et al.

Summary: Mutations in Ryanodine receptor type 2 (RyR2) have been found to be associated with an inherited form of exercise-induced sudden cardiac death called catecholaminergic polymorphic ventricular tachycardia (CPVT). This study presents atomic models of the human wild-type (WT) RyR2 and the CPVT mutant RyR2-R2474S, revealing the mechanism of CPVT and the therapeutic actions of the Rycal drug ARM210.

SCIENCE ADVANCES (2022)

Add to Collection

Article Biophysics

Functional and Structural Interactions between Ca2+, ATP and Caffeine Binding Sites of Skeletal Muscle Ryanodine Receptor (RyR1)

Venkat R. Chirasani et al.

BIOPHYSICAL JOURNAL (2021)

Add to Collection

Article Multidisciplinary Sciences

Pathological conformations of disease mutant Ryanodine Receptors revealed by cryo-EM

Kellie A. Woll et al.

Summary: Ryanodine Receptors (RyRs) release Ca2+ and mutations in RyR can lead to various diseases such as malignant hyperthermia, myopathies, and arrhythmias. By investigating an MH-related RyR mutation and how apoCaM induces RyR1 opening, it is shown that disease mutations can cause distinct pathological conformations of RyR, affecting channel opening.

NATURE COMMUNICATIONS (2021)

Add to Collection

Article Neurosciences

RyR1-related myopathy mutations in ATP and calcium binding sites impair channel regulation

Qi Yuan et al.

Summary: RyR1 is a crucial intracellular Ca2+ release channel modulated by Ca2+ and ATP. Mutations at the Ca2+ and ATP binding sites can impair channel function and potentially contribute to RyR1-related myopathy.

ACTA NEUROPATHOLOGICA COMMUNICATIONS (2021)

Add to Collection

Article Biology

Intracellular ATP Concentration and Implication for Cellular Evolution

Jack Greiner et al.

Summary: The lens and muscle tissues have high concentrations of ATP despite low metabolic requirements, suggesting a non-metabolic function of ATP in cellular and tissue function evolution.

BIOLOGY-BASEL (2021)

Add to Collection

Review Biochemistry & Molecular Biology

Structure and function of STAC proteins: Calcium channel modulators and critical components of muscle excitation-contraction coupling

Britany Rufenach et al.

Summary: This review focuses on the mechanical coupling between Ca(V)1.1 and RyR1 in skeletal muscle tissue, the role of STAC3 as a critical player in this coupling, and the relevance of these connections for functional modulation and involvement in myopathy.

JOURNAL OF BIOLOGICAL CHEMISTRY (2021)

Add to Collection

Review Cardiac & Cardiovascular Systems

Intracellular calcium leak in heart failure and atrial fibrillation: a unifying mechanism and therapeutic target

Haikel Dridi et al.

NATURE REVIEWS CARDIOLOGY (2020)

Add to Collection

Article Biochemistry & Molecular Biology

Structural basis for diamide modulation of ryanodine receptor

Ruifang Ma et al.

NATURE CHEMICAL BIOLOGY (2020)

Add to Collection

Review Endocrinology & Metabolism

Sarcopenia and Muscle Aging: A Brief Overview

Tam Dao et al.

ENDOCRINOLOGY AND METABOLISM (2020)

Add to Collection

Review Endocrinology & Metabolism

Skeletal muscle energy metabolism during exercise

Mark Hargreaves et al.

NATURE METABOLISM (2020)

Add to Collection

Article Biochemistry & Molecular Biology

The Cardiac Ryanodine Receptor Phosphorylation Hotspot Embraces PKA in a Phosphorylation-Dependent Manner

Omid Haji-Ghassemi et al.

MOLECULAR CELL (2019)

Add to Collection

Article Pharmacology & Pharmacy

Dantrolene Requires Mg2+ and ATP To Inhibit the Ryanodine Receptor

Gyula Diszhazi et al.

MOLECULAR PHARMACOLOGY (2019)

Add to Collection

Article Biochemistry & Molecular Biology

UCSF ChimeraX: Meeting modern challenges in visualization and analysis

Thomas D. Goddard et al.

PROTEIN SCIENCE (2018)

Add to Collection

Article Anesthesiology

Updated guide for the management of malignant hyperthermia

Sheila Riazi et al.

CANADIAN JOURNAL OF ANESTHESIA-JOURNAL CANADIEN D ANESTHESIE (2018)

Add to Collection

Article Biochemical Research Methods

Real-space refinement in PHENIX for cryo-EM and crystallography

Pavel V. Afonine et al.

ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY (2018)

Add to Collection

Review Genetics & Heredity

Calcium Channelopathies: Structural Insights into Disorders of the Muscle Excitation-Contraction Complex

Raika Pancaroglu et al.

ANNUAL REVIEW OF GENETICS, VOL 52 (2018)

Add to Collection

Article Multidisciplinary Sciences

Promiscuous attraction of ligands within the ATP binding site of RyR2 promotes diverse gating behaviour

Chris Lindsay et al.

SCIENTIFIC REPORTS (2018)

Add to Collection

Article Biology

A tryptophan residue in the caffeine-binding site of the ryanodine receptor regulates Ca2+ sensitivity

Takashi Murayama et al.

COMMUNICATIONS BIOLOGY (2018)

Add to Collection

Article Biochemical Research Methods

cryoSPARC: algorithms for rapid unsupervised cryo-EM structure determination

Ali Punjani et al.

NATURE METHODS (2017)

Add to Collection

Article Anesthesiology

Diagnosis and management of malignant hyperthermia

Pawan K. Gupta et al.

BJA EDUCATION (2017)

Add to Collection

Article Biochemistry & Molecular Biology

Structural Basis for Gating and Activation of RyR1

Amedee des Georges et al.

CELL (2016)

Add to Collection

Article Physiology

Structure-function relationships of peptides forming the calcin family of ryanodine receptor ligands

Liang Xiao et al.

JOURNAL OF GENERAL PHYSIOLOGY (2016)

Add to Collection

Article Cardiac & Cardiovascular Systems

CaMKII-dependent phosphorylation of RyR2 promotes targetable pathological RyR2 conformational shift

Hitoshi Uchinoumi et al.

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2016)

Add to Collection

Article Biochemistry & Molecular Biology

The CPVT-associated RyR2 mutation G230C enhances store overload-induced Ca2+ release and destabilizes the N-terminal domains

Yingjie Liu et al.

BIOCHEMICAL JOURNAL (2013)

Add to Collection

Article Multidisciplinary Sciences

Stac3 is a component of the excitation-contraction coupling machinery and mutated in Native American myopathy

Eric J. Horstick et al.

NATURE COMMUNICATIONS (2013)

Add to Collection

Article Biochemistry & Molecular Biology

AICAR prevents heat-induced sudden death in RyR1 mutant mice independent of AMPK activation

Johanna T. Lanner et al.

NATURE MEDICINE (2012)

Add to Collection

Review Endocrinology & Metabolism

AMPK functions as an adenylate charge-regulated protein kinase

Jonathan S. Oakhill et al.

TRENDS IN ENDOCRINOLOGY AND METABOLISM (2012)

Add to Collection

Article

Muscle Magnetic Resonance Imaging in Congenital Myopathies Due to Ryanodine Receptor Type 1 Gene Mutations

Andrea Klein

ARCHIVES OF NEUROLOGY (2011)

Add to Collection

Article Biophysics

Single Ryanodine Receptor Channel Basis of Caffeine's Action on Ca2+ Sparks

Maura Porta et al.

BIOPHYSICAL JOURNAL (2011)

Add to Collection

Article Cell Biology

Ryanodine Receptor Oxidation Causes Intracellular Calcium Leak and Muscle Weakness in Aging

Daniel C. Andersson et al.

CELL METABOLISM (2011)

Add to Collection

Article Biochemical Research Methods

Features and development of Coot

P. Emsley et al.

ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY (2010)

Add to Collection

Article Cell Biology

Ryanodine Receptors: Structure, Expression, Molecular Details, and Function in Calcium Release

Johanna T. Lanner et al.

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2010)

Add to Collection

Article Biochemistry & Molecular Biology

Effects of Small Molecule Modulators on ATP Binding to Skeletal Ryanodine Receptor

Jose M. Dias et al.

PROTEIN JOURNAL (2009)

Add to Collection

Article Cell Biology

Cytoplasmic cAMP concentrations in intact cardiac myocytes

Radu V. Iancu et al.

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2008)

Add to Collection

Review Genetics & Heredity

Mutations in RYR1 in malignant hyperthermia and central core disease

Rachel Robinson et al.

HUMAN MUTATION (2006)

Add to Collection

Article Biochemistry & Molecular Biology

Insights into the regulation of the ryanodine receptor:: Differential effects of Mg2+ and Ca2+ on ATP binding

Jose M. Dias et al.

BIOCHEMISTRY (2006)

Add to Collection

Article Biochemistry & Molecular Biology

Ser-2030, but not Ser-2808, is the major phosphorylation site in cardiac ryanodine receptors responding to protein kinase A activation upon β-adrenergic stimulation in normal and failing hearts

Bailong Xiao et al.

BIOCHEMICAL JOURNAL (2006)

Add to Collection

Article Chemistry, Multidisciplinary

UCSF chimera - A visualization system for exploratory research and analysis

EF Pettersen et al.

JOURNAL OF COMPUTATIONAL CHEMISTRY (2004)

Add to Collection

Article Neurosciences

Sarcoplasmic reticulum calcium release compared in slow-twitch and fast-twitch fibres of mouse muscle

SM Baylor et al.

JOURNAL OF PHYSIOLOGY-LONDON (2003)

Add to Collection

Article Biochemistry & Molecular Biology

PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): Defective regulation in failing hearts

SO Marx et al.

CELL (2000)

Add to Collection

© Peeref 2019-2024. All rights reserved.