4.7 Review

Perspective Review of Myeloid Immune Cell Responses and Poststroke Immunosuppression

Related references

Note: Only part of the references are listed.
Article Pharmacology & Pharmacy

Glycolysis inhibition ameliorates brain injury after ischemic stroke by promoting the function of myeloid-derived suppressor cells

Jingwei Yan et al.

Summary: The study found that MDSCs appear in the blood of stroke patients in the early stage, and similar results were observed in a rat brain model induced by temporary middle cerebral artery occlusion. The research showed that pharmaceutical depletion of MDSCs worsens ischemic brain injury, while adoptive transfer of MDSCs can rescue the damage.

PHARMACOLOGICAL RESEARCH (2022)

Review Medicine, Research & Experimental

Systemic inflammation after stroke: implications for post-stroke comorbidities

Alba Simats et al.

Summary: This review summarizes the impact of ischemic stroke on systemic immunity and comorbidities associated with stroke, as well as discusses the underlying mechanisms. The research suggests that modulating the immune system could improve the treatment outcomes and prognosis of stroke, as well as alleviate comorbidities.

EMBO MOLECULAR MEDICINE (2022)

Review Clinical Neurology

Gut Microbiota in Ischemic Stroke: Role of Gut Bacteria-Derived Metabolites

Wei Zhang et al.

Summary: Ischemic stroke (IS) is a major cause of death and long-term disability globally. Recent studies have shown that gut microbiota dysbiosis is closely related to cardiovascular diseases, which are the main risk factors for IS. IS may lead to gut dysbiosis and increased intestinal permeability, resulting in harmful effects on organs such as the brain.

TRANSLATIONAL STROKE RESEARCH (2022)

Article Endocrinology & Metabolism

Distinct peripheral blood monocyte and neutrophil transcriptional programs following intracerebral hemorrhage and different etiologies of ischemic stroke

Paulina Carmona-Mora et al.

Summary: In both IS and ICH, monocyte genes were down-regulated, whereas neutrophil gene expression changes were generally up-regulated. The monocyte down-regulated response to ICH included innate, adaptive immune, dendritic, NK cell and atherosclerosis signaling. Neutrophil responses to ICH included tRNA charging, mitochondrial dysfunction, and ER stress pathways. Common monocyte and neutrophil responses to ICH included interferon signaling, neuroinflammation, death receptor signaling, and NFAT pathways.

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2021)

Review Pharmacology & Pharmacy

Ischemic stroke and infection: A brief update on mechanisms and potential therapies

Drishti P. Ghelani et al.

Summary: Ischemic stroke induces a multifaceted inflammatory response and immunosuppression, increasing the risk of opportunistic infections. Gut flora may contribute to post-stroke infections, highlighting the importance of protecting and restoring the gut microbiota. Careful administration of therapies for ischemic stroke is essential due to the complex interplay between brain inflammation, post-stroke immunosuppression, and infection risk.

BIOCHEMICAL PHARMACOLOGY (2021)

Article Emergency Medicine

Risk factors for acute stroke-associated pneumonia and prediction of neutrophil-to-lymphocyte ratios

Quanpeng Wang et al.

Summary: The study identified risk factors for stroke-associated pneumonia (SAP) in acute stroke patients, including cerebral hemorrhage, indwelling nasogastric tube, and high NLR. Early NLR had predictive value for the occurrence of SAP in patients with acute stroke.

AMERICAN JOURNAL OF EMERGENCY MEDICINE (2021)

Article Immunology

Post-injury immunosuppression and secondary infections are caused by an AIM2 inflammasome-driven signaling cascade

Stefan Roth et al.

Summary: T cell death after acute injury is mainly driven by monocyte-T cell interaction, leading to extrinsic T cell apoptosis through IL-1 beta secretion after sensing extracellular DNA. Pharmacological inhibition of this pathway can improve T cell survival and reduce infections.

IMMUNITY (2021)

Review Endocrinology & Metabolism

Targeting neutrophils as a novel therapeutic strategy after stroke

Chen Chen et al.

Summary: After a stroke, the intricate immune response involving various immune cells, including neutrophils, plays a crucial role in ischemic brain damage. The heterogeneity of neutrophils and their diverse roles in different conditions are still being studied, with single-cell RNA sequencing providing new insights. Potential therapeutic strategies targeting neutrophils to limit brain damage following ischemic stroke are being explored.

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2021)

Article Clinical Neurology

Neutrophil-to-Lymphocyte Ratio Predicts Cerebral Edema and Clinical Worsening Early After Reperfusion Therapy in Stroke

Daniela Ferro et al.

Summary: The study revealed that increased systemic inflammation following reperfusion therapy is associated with a higher severity of cerebral edema in stroke patients, leading to hindered clinical recovery. The neutrophil-to-lymphocyte ratio was identified as the best predictive marker, providing early warning alerts for patients at risk of severe neurological complications.

STROKE (2021)

Article Immunology

Role of TLR4 in Neutrophil Dynamics and Functions: Contribution to Stroke Pathophysiology

Violeta Duran-Laforet et al.

Summary: The absence of TLR4 in neutrophils leads to smaller infarct volumes after ischemic stroke. TLR4-lacking neutrophils remain in a steady youth status and show higher phagocytic activity, preferential engulfment by microglia, and reduced production of ROS in the initial stages of inflammation post-stroke. These findings suggest that targeting TLR4 in specific cell types, especially neutrophils, may be a potential strategy for neuroprotection.

FRONTIERS IN IMMUNOLOGY (2021)

Article Behavioral Sciences

Monocyte-to-lymphocyte ratio as a predictor of stroke-associated pneumonia: A retrospective study-based investigation

Feng Cao et al.

Summary: This study found that a high MLR is an independent risk factor for SAP and has a predictive value for severe pneumonia in patients with SAP.

BRAIN AND BEHAVIOR (2021)

Review Immunology

The Neutrophil

Garth Lawrence Burn et al.

Summary: Neutrophils are immune cells with potent antimicrobial properties, capable of efficiently killing microorganisms both intracellularly and extracellularly. In addition to fighting infections, they can use their toxic machinery in other contexts such as cancer. However, inappropriate or dysregulated activation of neutrophils can lead to host damage and contribute to autoimmune and inflammatory diseases.

IMMUNITY (2021)

Article Biochemistry & Molecular Biology

Acute Lung Injury in Cholinergic-Deficient Mice Supports Anti-Inflammatory Role of α7 Nicotinic Acetylcholine Receptor

Nathalia M. Pinheiro et al.

Summary: In acute lung injury, inflammatory markers are significantly elevated in cholinergic-deficient mice compared to wild-type, but treatment with the selective alpha 7 nicotinic receptor agonist PNU 282987 can restore the response and reduce lung inflammation. The anti-inflammatory effects of the lung cholinergic system are associated with an increase in the level of alpha 7 nicotinic receptors, suggesting potential clinical applications for treating acute lung injury.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Review Immunology

Stroke-induced immunosuppression: implications for the prevention and prediction of post-stroke infections

Julia Faura et al.

Summary: Stroke-induced immunosuppression increases the risk of stroke-associated infections in stroke patients, particularly stroke-associated pneumonia, but there are currently no accurate biomarkers for early diagnosis and prevention. Efforts are being made to explore local immunomodulation as a potential approach for preventive therapy of stroke-associated pneumonia.

JOURNAL OF NEUROINFLAMMATION (2021)

Article Clinical Neurology

Functional Dynamics of Neutrophils After Ischemic Stroke

Wei Cai et al.

TRANSLATIONAL STROKE RESEARCH (2020)

Review Pharmacology & Pharmacy

The role of neutrophils in neuro-immune modulation

Alexandre Kanashiro et al.

PHARMACOLOGICAL RESEARCH (2020)

Article Immunology

Stroke Exacerbates Cancer Progression by Upregulating LCN2 in PMN-MDSC

Tingting Huang et al.

FRONTIERS IN IMMUNOLOGY (2020)

Review Medicine, Research & Experimental

Immune responses to stroke: mechanisms, modulation, and therapeutic potential

Costantino Iadecolar et al.

JOURNAL OF CLINICAL INVESTIGATION (2020)

Review Hematology

Neutrophil plasticity in the tumor microenvironment

Morgan A. Giese et al.

BLOOD (2019)

Article Cardiac & Cardiovascular Systems

Glucocorticoids Regulate Bone Marrow B Lymphopoiesis After Stroke

Gabriel Courties et al.

CIRCULATION RESEARCH (2019)

Review Immunology

Biological Roles Of Neutrophil-Derived Granule Proteins and Cytokines

Marco Antonio Cassatella et al.

TRENDS IN IMMUNOLOGY (2019)

Review Immunology

Neuroinflammation: friend and foe for ischemic stroke

Richard L. Jayaraj et al.

JOURNAL OF NEUROINFLAMMATION (2019)

Review Immunology

Neutrophil Diversity in Health and Disease

Carlos Silvestre-Roig et al.

TRENDS IN IMMUNOLOGY (2019)

Article Clinical Neurology

Harmful neutrophil subsets in patients with ischemic stroke Association with disease severity

David Weisenburger-Lile et al.

NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION (2019)

Review Immunology

More Than Suppression: Glucocorticoid Action on Monocytes and Macrophages

Jan M. Ehrchen et al.

FRONTIERS IN IMMUNOLOGY (2019)

Article Clinical Neurology

Role of TLR4 (Toll-Like Receptor 4) in N1/N2 Neutrophil Programming After Stroke

Alicia Garcia-Culebras et al.

STROKE (2019)

Article Immunology

The Myeloid Cell Compartment—Cell by Cell

Kevin Bassler et al.

Annual Review of Immunology (2019)

Article Cell Biology

Activation of the sympathetic nervous system modulates neutrophil function

Alyce J. Nicholls et al.

JOURNAL OF LEUKOCYTE BIOLOGY (2018)

Article Clinical Neurology

High Neutrophil-to-Lymphocyte Ratio Predicts Stroke-Associated Pneumonia

Ki-Woong Nam et al.

STROKE (2018)

Review Clinical Neurology

Stroke-induced immunosuppression and poststroke infection

Kaibin Shi et al.

STROKE AND VASCULAR NEUROLOGY (2018)

Review Immunology

Developmental and Functional Heterogeneity of Monocytes

Martin Guilliams et al.

IMMUNITY (2018)

Review Biochemistry & Molecular Biology

How Glucocorticoids Affect the Neutrophil Life

Simona Ronchetti et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

Review Medicine, General & Internal

Antibiotic therapy for preventing infections in people with acute stroke

Jan-Dirk Vermeij et al.

COCHRANE DATABASE OF SYSTEMATIC REVIEWS (2018)

Article Multidisciplinary Sciences

Neutrophil polarization by IL-27 as a therapeutic target for intracerebral hemorrhage

Xiurong Zhao et al.

NATURE COMMUNICATIONS (2017)

Review Immunology

Immune regulation by glucocorticoids

Derek W. Cain et al.

NATURE REVIEWS IMMUNOLOGY (2017)

Review Biochemistry & Molecular Biology

HMGB1 as a Key Mediator of Immune Mechanisms in Ischemic Stroke

Vikramjeet Singh et al.

ANTIOXIDANTS & REDOX SIGNALING (2016)

Review Medicine, General & Internal

Ischemic stroke outcome: A review of the influence of post-stroke complications within the different scenarios of stroke care

Alejandro Bustamante et al.

EUROPEAN JOURNAL OF INTERNAL MEDICINE (2016)

Article Biochemistry & Molecular Biology

Translocation and dissemination of commensal bacteria in post-stroke infection

Dragana Stanley et al.

NATURE MEDICINE (2016)

Review Critical Care Medicine

Immunomodulation after ischemic stroke: potential mechanisms and implications for therapy

Cynthia Santos Samary et al.

CRITICAL CARE (2016)

Review Biochemistry & Molecular Biology

Ischemia, Immunosuppression and Infection-Tackling the Predicaments of Post-Stroke Complications

Raymond Shim et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2016)

Article Endocrinology & Metabolism

Arginase I release from activated neutrophils induces peripheral immunosuppression in a murine model of stroke

Trisha R. Sippel et al.

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2015)

Article Cardiac & Cardiovascular Systems

Ischemic Stroke Activates Hematopoietic Bone Marrow Stem Cells

Gabriel Courties et al.

CIRCULATION RESEARCH (2015)

Article Endocrinology & Metabolism

Role of spleen-derived monocytes/macrophages in acute ischemic brain injury

Eunhee Kim et al.

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2014)

Article Biochemistry & Molecular Biology

Chronic variable stress activates hematopoietic stem cells

Timo Heidt et al.

NATURE MEDICINE (2014)

Article Clinical Neurology

Stroke Alters Respiratory Burst in Neutrophils and Monocytes

Johanna Ruhnau et al.

STROKE (2014)

Review Immunology

Monocytes and macrophages: developmental pathways and tissue homeostasis

Florent Ginhoux et al.

NATURE REVIEWS IMMUNOLOGY (2014)

Article Multidisciplinary Sciences

Stress Mediators and Immune Dysfunction in Patients with Acute Cerebrovascular Diseases

Arthur Liesz et al.

PLOS ONE (2013)

Article Multidisciplinary Sciences

Relevance of Distinct Monocyte Subsets to Clinical Course of Ischemic Stroke Patients

Muichi Kaito et al.

PLOS ONE (2013)

Article Clinical Neurology

Novel Risk Score to Predict Pneumonia After Acute Ischemic Stroke

Ruijun Ji et al.

STROKE (2013)

Article Biochemistry & Molecular Biology

Stroke-induced activation of the α7 nicotinic receptor increases Pseudomonas aeruginosa lung injury

Mathieu Lafargue et al.

FASEB JOURNAL (2012)

Article Clinical Neurology

Impact of infections on long-term outcome after severe middle cerebral artery infarction

Lena Ulm et al.

JOURNAL OF THE NEUROLOGICAL SCIENCES (2012)

Review Clinical Neurology

The immunology of acute stroke

Angel Chamorro et al.

NATURE REVIEWS NEUROLOGY (2012)

Article Clinical Neurology

Post-stroke infection: A systematic review and meta-analysis

Willeke F. Westendorp et al.

BMC NEUROLOGY (2011)

Article Clinical Neurology

Influence of Stroke Localization on Autonomic Activation, Immunodepression, and Post-Stroke Infection

Hendrik Harms et al.

CEREBROVASCULAR DISEASES (2011)

Article Multidisciplinary Sciences

Functional Innervation of Hepatic iNKT Cells Is Immunosuppressive Following Stroke

Connie H. Y. Wong et al.

SCIENCE (2011)

Article Biochemistry & Molecular Biology

The role of the glucocorticoid receptor in inflammation and immunity

Ulrike Baschant et al.

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY (2010)

Review Pharmacology & Pharmacy

Arginase: an emerging key player in the mammalian immune system

Markus Munder

BRITISH JOURNAL OF PHARMACOLOGY (2009)

Article Neurosciences

Blockade of adrenoreceptors inhibits the splenic response to stroke

Craig T. Ajmo et al.

EXPERIMENTAL NEUROLOGY (2009)

Article Endocrinology & Metabolism

Monocyte subtypes predict clinical course and prognosis in human stroke

Xabier Urra et al.

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2009)

Article Multidisciplinary Sciences

Preventive Antibacterial Therapy in Acute Ischemic Stroke: A Randomized Controlled Trial

Hendrik Harms et al.

PLOS ONE (2008)

Review Immunology

Exploring the full spectrum of macrophage activation

David M. Mosser et al.

NATURE REVIEWS IMMUNOLOGY (2008)

Review Medicine, Research & Experimental

Physiology and immunology of the cholinergic antiinflammatory pathway

Kevin J. Tracey

JOURNAL OF CLINICAL INVESTIGATION (2007)

Article Clinical Neurology

Catecholamines, infection, and death in acute ischemic stroke

Angel Chamorro et al.

JOURNAL OF THE NEUROLOGICAL SCIENCES (2007)

Article Cardiac & Cardiovascular Systems

Functional and phenotypic changes in polymorphonuclear neutrophils induced by catecholamines

B. Trabold et al.

SCANDINAVIAN CARDIOVASCULAR JOURNAL (2007)

Article Clinical Neurology

Interleukin 10, monocytes and increased risk of early infection in ischaemic stroke

A. Chamorro et al.

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY (2006)

Review Rheumatology

Macrophage migration inhibitory factor and glucocorticoid sensitivity

D. Aeberli et al.

RHEUMATOLOGY (2006)

Review Pharmacology & Pharmacy

Complexity of the bi-directional neuroimmune junction in the spleen

RH Straub

TRENDS IN PHARMACOLOGICAL SCIENCES (2004)

Article Medicine, General & Internal

Low and high circulating cortisol levels predict mortality and cognitive dysfunction early after stroke

N Marklund et al.

JOURNAL OF INTERNAL MEDICINE (2004)

Article Multidisciplinary Sciences

Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin

LV Borovikova et al.

NATURE (2000)