Generation of two induced pluripotent stem cell lines with heterozygous and homozygous amyotrophic lateral sclerosis-causing mutation R521G (c.1561C > G) in FUS gene

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Modeling Movement Disorders via Generation of hiPSC-Derived Motor Neurons

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Summary: This article discusses the generation of motor neurons (MNs) from hiPSCs and focuses on two approaches: induction by small molecules and induction by lentiviral delivery of transcription factors. The challenges in modeling neurological diseases using iPSC-derived neurons are identified, including obtaining high purity and yield of neurons, achieving full maturation in long-term culture, and culturing neurons more physiologically to maximize relevance to in vivo conditions.

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Article Cell & Tissue Engineering

Generation of gene-corrected isogenic control cell lines from a DYT1 dystonia patient iPSC line carrying a heterozygous GAG mutation in TOR1A gene

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Summary: Childhood-onset torsin dystonia (DYT1) is a rare hereditary movement disorder caused by GAG deletion in the TOR1A gene. This study generated isogenic control lines using hiPSC technology, providing a valuable resource for DYT1 research.

STEM CELL RESEARCH (2022)

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Article Cell & Tissue Engineering

Generation of two induced pluripotent stem cell lines with heterozygous and homozygous GAG deletion in TOR1A gene from a healthy hiPSC line

Masuma Akter et al.

Summary: This study successfully generated human induced pluripotent stem cell lines with TOR1A gene GAG deletions through genetic modification, providing a valuable resource in determining the pathogenesis of DYT1 dystonia.

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Article Cell Biology

Generation and optimization of highly pure motor neurons from human induced pluripotent stem cells via lentiviral delivery of transcription factors

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Generation of two induced pluripotent stem cell lines with heterozygous and homozygous amyotrophic lateral sclerosis-causing mutation R521G (c.1561C > G) in FUS gene

Related references

FUS ALS neurons activate major stress pathways and reduce translation as an early protective mechanism against neurodegeneration

Modeling Movement Disorders via Generation of hiPSC-Derived Motor Neurons

Generation of gene-corrected isogenic control cell lines from a DYT1 dystonia patient iPSC line carrying a heterozygous GAG mutation in TOR1A gene

Generation of two induced pluripotent stem cell lines with heterozygous and homozygous GAG deletion in TOR1A gene from a healthy hiPSC line

Generation and optimization of highly pure motor neurons from human induced pluripotent stem cells via lentiviral delivery of transcription factors

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