Generation of four human induced pluripotent stem cell lines from COVID-19 hospitalized patients with increased levels of cardiac Troponin in the acute infection phase developing or not myocarditis

Coronavirus disease (COVID-19) is an infectious disease caused by SARS-CoV-2 virus, leading to mild to severe respiratory symptoms. Cardiovascular involvement is frequent and mainly manifests with myocarditis, arrhythmias, cardiac arrests, heart failure and coagulation abnormality. We generated human induced pluripotent stem cells (hiPSCs) from four COVID-19 patients, all characterized by increased levels of high-sensitivity Troponin I (hsTnI) during the infection acute phase, who developed (n = 2) or not (n = 2) severe myocarditis, as COVID-19 complication. The established hiPSCs were characterized for pluripotency and genomic stability, and constitute a useful resource for studying the mechanisms underlying the variability in COVID-19 severe cardiac manifestations.

Automated summary

Coronavirus disease (COVID-19) is caused by SARS-CoV-2 and can lead to respiratory symptoms. Cardiovascular complications are common, including myocarditis, arrhythmias, heart failure, and coagulation abnormalities. In this study, hiPSCs were generated from four COVID-19 patients, two with severe myocarditis and two without, to study the mechanisms underlying the variability in severe cardiac manifestations.