4.8 Article

Construction of Exosome SORL1 Detection Platform Based on 3D Porous Microfluidic Chip and its Application in Early Diagnosis of Colorectal Cancer

Related references

Note: Only part of the references are listed.
Review Nanoscience & Nanotechnology

In vitro diagnostic technologies for the detection of extracellular vesicles: current status and future directions

Shuya Song et al.

Summary: Extracellular vesicles (EVs) are natural vehicles that play key roles in intercellular communication and have potential as biomarkers for disease diagnosis. This review summarizes the current methods for isolating EVs from body fluids and techniques for analyzing their biomolecules. The advantages, feasibility, and challenges of EV-based in vitro diagnosis are discussed, along with an outlook on the marketing and routine clinical application of EV-based diagnosis.
Review Nanoscience & Nanotechnology

Advanced mass spectrometric and spectroscopic methods coupled with machine learning for in vitro diagnosis

Xiaonan Chen et al.

Summary: In vitro diagnosis (IVD) is an important part of medical tests for detecting biological samples. Mass spectrometry and spectroscopy are increasingly used in IVD due to their accuracy and efficiency. Machine learning has emerged as a promising solution for decoding big data generated by these techniques. This review provides a comprehensive summary of ML-assisted mass spectrometry and spectroscopy in IVD, aiming to facilitate the development of these techniques.
Review Nanoscience & Nanotechnology

Microfluidic single-cell multiomics analysis

Xing Xu et al.

Summary: Cellular heterogeneity is crucial for biological processes. In recent years, the development of single-cell multiomics technologies has allowed for comprehensive evaluation of single-cell heterogeneity. Microfluidics plays a significant role in single-cell multiomics analysis, enabling improved detection sensitivity, accuracy, throughput, and integration. This review provides an overview of the latest microfluidic single-cell multiomics analysis techniques, as well as their potential in biological and clinical applications.
Review Engineering, Biomedical

Droplet microfluidics-base d biome dical microcarriers

Changmin Shao et al.

Summary: Droplet microfluidic technology is a new platform for controlling the generation of microdroplets and droplet-derived materials. It has unique advantages in the preparation of functional microcarriers and is widely used in the areas of cell culture, tissue engineering, and drug delivery.

ACTA BIOMATERIALIA (2022)

Article Biochemical Research Methods

A numerical approach for detecting switch-like bistability in mass action chemical reaction networks with conservation laws

Brandon C. Reyes et al.

Summary: In this study, a generalized method for detecting switch-like bistable behavior in any mass action reaction network with conservation laws was developed. The method involves construction of a constrained optimization problem, minimization of the objective function to search for conditions leading to a zero eigenvalue, computation of a confidence level, and evaluation of optimization values to verify the existence of a bistability region. The method has been successfully tested on three motifs capable of bistability.

BMC BIOINFORMATICS (2022)

Article Chemistry, Multidisciplinary

High-Throughput DNA Tensioner Platform for Interrogating Mechanical Heterogeneity of Single Living Cells

Xinxin Hang et al.

Summary: This study introduces a DNA tensioner platform with high throughput and pN-level resolution to detect the mechanical forces of individual cells. Using this platform, enhanced mechanical forces in drug-resistant cells and metastatic tumor cells, as well as the mechanical heterogeneity associated with genes VEGFA and MINK1, were identified. The platform has the potential to establish links between cellular mechanical heterogeneity and genetic heterogeneity.

SMALL (2022)

Review Chemistry, Analytical

Advanced on-site and in vitro signal amplification biosensors for biomolecule analysis

Yuning Wang et al.

Summary: Point-of-care testing (POCT) plays an important role in early diagnosis and personalized treatment in clinics. Signal amplified biosensors are used to detect biomarkers with low abundance, in combination with advanced techniques.

TRAC-TRENDS IN ANALYTICAL CHEMISTRY (2022)

Book Review Biochemical Research Methods

Magnetic micro-/nano-materials for proteomics analysis

Kun Qian

ANALYTICAL AND BIOANALYTICAL CHEMISTRY (2022)

Article Materials Science, Multidisciplinary

Advanced materials for precise detection and antibiotic-free inhibition of bacteria

W. Liu et al.

Summary: Infections caused by harmful bacteria are a major global public health concern, exacerbated by the emergence of multidrug-resistant pathogens due to antibiotic abuse. This review highlights the need for advanced materials in precise pathogen detection and inhibition. It discusses recent advancements in pathogen detection using advanced materials and analytical approaches, as well as the antibacterial applications of these materials.

MATERIALS TODAY ADVANCES (2022)

Article Chemistry, Analytical

Deep Learning Framework for Integrating Multibatch Calibration, Classification, and Pathway Activities

JingYang Niu et al.

Summary: By proposing a joint deep learning framework that integrates batch effect removal, classification, and downstream pathway activities, we have validated its effectiveness on metabolomics datasets, achieving higher diagnostic accuracy and notable improvement over other methods.

ANALYTICAL CHEMISTRY (2022)

Article Chemistry, Multidisciplinary

A One-Stop Shop Decision Tree for Diagnosing and Phenotyping Polycystic Ovarian Syndrome on Serum Metabolic Fingerprints

Ruimin Wang et al.

Summary: This study introduces a nanoparticle-enhanced laser desorption/ionization mass spectrometry platform for one-time serum metabolic fingerprinting in PCOS patients with obesity. A decision tree is constructed to diagnose and phenotype PCOS patients, showing high accuracy and technical robustness.

ADVANCED FUNCTIONAL MATERIALS (2022)

Review Nanoscience & Nanotechnology

Using all our genomes: Blood-based liquid biopsies for the early detection of cancer

Eddie Adams et al.

Summary: The pursuit of highly sensitive and specific cancer diagnostics based on cell-free nucleic acids is a research and commercial effort for at least two decades. Using ctDNA for the diagnosis of early-stage cancers remains challenging due to several factors.
Article Automation & Control Systems

Emerging Applications of Mass Spectrometry-Based Metabolic Fingerprinting in Clinics

Jing Cao et al.

Summary: Recent developments in mass spectrometry-based metabolic fingerprinting analysis have facilitated its practical clinical applications by addressing challenges such as rapid signal readout, high throughput, direct MS analysis, and intelligent data mining of complex biological samples.

ADVANCED INTELLIGENT SYSTEMS (2022)

Article Chemistry, Analytical

DNA Nanomachines for Identifying Cancer Biomarkers in Body Fluids and Cells

Zaizai Dong et al.

Summary: DNA nanomachines, designable and switchable nanostructures made of DNA, have great potential for early detection of cancer biomarkers with advantages of noninvasiveness, affordability, high sensitivity, and high specificity. This summary highlights recent DNA nanomachine-based platforms for detecting cancer biomarkers, both from body fluids and in cells.

ANALYTICAL CHEMISTRY (2021)

Review Cell & Tissue Engineering

Advances in mesenchymal stem cell exosomes: a review

Yaya Tang et al.

Summary: Stem cells are valuable in regenerative medicine and disease treatment, but face challenges such as storage limitations and cell senescence. Exosomes, as an alternative, have similar effects to stem cells and offer advantages such as targeted delivery, low immunogenicity, and high repairability.

STEM CELL RESEARCH & THERAPY (2021)

Editorial Material Gastroenterology & Hepatology

Microbiome distinctions between the CRC carcinogenic pathways

Lauren DeDecker et al.

Summary: Colorectal cancer is on the rise among young adults in the United States, and understanding the role of the microbiome in CRC development through different pathways could lead to novel prevention, screening, and therapeutic interventions. Key findings from human studies include associations between specific bacteria and CRC characteristics, such as location and histopathologic type.

GUT MICROBES (2021)

Article Chemistry, Physical

Metal-Organic Framework Hybrids Aid Metabolic Profiling for Colorectal Cancer

Xinxing Li et al.

Summary: A novel molecular tool based on metal-organic framework (MOF) hybrids is developed for metabolic analysis in colorectal cancer (CRC), providing direct metabolic fingerprints in seconds. A machine learning algorithm is utilized to construct a diagnostic prediction model to discriminate CRC patients from normal controls, with an average area under the curve of 0.947 for the discovery cohort and 0.912 for the independent validation cohort. Additionally, a CRC-specific metabolic signature consisting of 34 potential biomarkers is identified based on the diagnostic model.

SMALL METHODS (2021)

Article Gastroenterology & Hepatology

ACG Clinical Guidelines: Colorectal Cancer Screening 2021

Aasma Shaukat et al.

Summary: This article provides an update on the 2009 American College of Gastroenterology CRC screening guidelines and discusses detailed recommendations for CRC screening in average-risk individuals and those with a family history of CRC, as well as the role of aspirin for chemoprevention, quality indicators for colonoscopy, organized CRC screening approaches, and improving adherence to CRC screening. The optimization of CRC screening is essential to effectively reduce CRC incidence and mortality, which can be achieved through high rates of adherence, quality monitoring, evidence-based guidelines, and the removal of barriers throughout the care spectrum. Developing cost-effective, highly accurate, noninvasive modalities to improve overall adherence to the screening process is also a desirable goal.

AMERICAN JOURNAL OF GASTROENTEROLOGY (2021)

Article Chemistry, Multidisciplinary

Nanoparticle-Assisted Cation Adduction and Fragmentation of Small Metabolites

Shiyu Sun et al.

Summary: This study investigated cation adduction and fragmentation of small metabolites using a combination of theoretical and experimental approaches, establishing rules and successfully controlling fragmentation to enhance metabolite identification and profiling. This work provides new insights for advanced analysis of small metabolites in mass spectrometry.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2021)

Review Oncology

Exosome-based liquid biopsies in cancer: opportunities and challenges

W. Yu et al.

Summary: Liquid biopsy in cancer research has seen significant progress, with efforts focused on utilizing circulating tumor cells, circulating tumor DNA, and extracellular vesicles like exosomes. Exosomes, as part of the intercellular communication system, carry tumor-derived materials and can serve as stable biomarkers for early detection and monitoring of cancer.

ANNALS OF ONCOLOGY (2021)

Article Oncology

Global colorectal cancer burden in 2020 and projections to 2040

Yue Xi et al.

Summary: Colorectal cancer is a major global public health challenge with higher incidence rates in developed countries and increasing trends in middle- and low-income countries. The rise of early-onset colorectal cancer is also seen. Increasing awareness, promoting healthy lifestyle choices, and implementing global screening programs are crucial in reducing the morbidity and mortality of colorectal cancer in the future.

TRANSLATIONAL ONCOLOGY (2021)

Article Biology

Framework for rapid comparison of extracellular vesicle isolation methods

Dmitry Ter-Ovanesyan et al.

Summary: This study demonstrates the use of ultrasensitive Simoa assays for quantifying EVs and comparing different isolation methods. The results highlight the utility of quantifying EV proteins using Simoa and provide a rapid framework for comparing and improving EV isolation methods.

ELIFE (2021)

Article Biophysics

Empirical Bayes method using surrounding pixel information for number and brightness analysis

Ryosuke Fukushima et al.

Summary: Number and brightness (N&B) analysis is a useful method for monitoring the spatial distribution of concentration and oligomeric state of fluorescently labeled proteins in cells. The proposed EB-MAP method improves the accuracy and precision in determining particle number and brightness compared with the traditional MoM method, making it valuable for studies on changes in cellular molecular mechanisms.

BIOPHYSICAL JOURNAL (2021)

Article Oncology

CCT8 recovers WTp53-suppressed cell cycle evolution and EMT to promote colorectal cancer progression

Qing Liao et al.

Summary: LASP1 and CCT8 can interact with each other in CRC cells and promote tumor progression. CCT8 promotes the growth and metastasis of CRC by inhibiting the entry of WTp53 into the nucleus. High expression of CCT8 leads to worse overall survival in CRC patients.

ONCOGENESIS (2021)

Article Genetics & Heredity

Identification and Mechanism of the PD-1/PD-L1 Genomic Signature SORL1 as Protective Factor in Bladder Cancer

Yajing Xu et al.

Summary: In this study, a predictive biomarker, SORL1, associated with the PD-1/PD-L1 signature was identified, showing a correlation with advanced BLCA stage and a negative association with PD-1/PD-L1 expression and M2 macrophage levels. Additionally, downregulation of SORL1 was found to be significantly related to higher EMT score. These findings suggest that SORL1 may have potential as a predictor for favorable outcomes in bladder cancer by reducing immune suppression and inhibiting M2 macrophage-induced EMT phenotype.

FRONTIERS IN GENETICS (2021)

Article Biochemistry & Molecular Biology

Hepato-protective role of chemo-preventive probiotics during DMH-induced CRC in rats

Sohini Walia et al.

Summary: The study demonstrated that probiotics Lactobacillus plantarum and Lactobacillus rhamnosus can effectively reduce hepatotoxicity and improve liver function, antioxidant enzyme activity, and lipid peroxidation in colorectal cancer prevention. This suggests that probiotics could be a safe and beneficial intervention in CRC.

JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY (2021)

Article Biochemistry & Molecular Biology

Development and validation of 3-CpG methylation prognostic signature based on different survival indicators for colorectal cancer

Hao Huang et al.

Summary: This study aimed to develop and validate novel methylation prognostic models correlated with different survival indicators for individualized prognosis prediction for CRC patients. The prognostic models were successfully developed and validated in TCGA CRC dataset and an independent CRC dataset, utilizing a combination of selected 3-CpG methylation sites in three genes.

MOLECULAR CARCINOGENESIS (2021)

Article Chemistry, Multidisciplinary

Single Living Cell Analysis Nanoplatform for High-Throughput Interrogation of Gene Mutation and Cellular Behavior

Zaizai Dong et al.

Summary: This study presents a novel single living cell analysis nanoplatform for interrogating gene properties and drug resistance simultaneously. By utilizing a specially designed Domino-probe and an on-chip addressable microwell-nanopore array, the system was validated in primary lung cancer cell samples, demonstrating a positive correlation between genes and cellular behaviors at the single-cell level.

NANO LETTERS (2021)

Article Oncology

Incidence, mortality, survival, risk factor and screening of colorectal cancer: A comparison among China, Europe, and northern America

Na Li et al.

Summary: This review examines the status and trends of CRC in China, Europe, and northern America, discussing preventive strategies and screening techniques. While some European and northern American countries have seen decreases in CRC incidence and mortality, China continues to experience increasing rates.

CANCER LETTERS (2021)

Review Oncology

Probiotics: A Promising Candidate for Management of Colorectal Cancer

Ashutosh Tripathy et al.

Summary: Colorectal cancer is the third most frequently diagnosed cancer type worldwide, with a mortality rate of about 9.4% of total cancer incidences in 2020. Probiotics have gained popularity as a potential candidate for the prevention and treatment of CRC due to their ability to improve intestinal health, secrete anticancer compounds, and modulate the immune system.

CANCERS (2021)

Review Gastroenterology & Hepatology

Strategies for Colorectal Cancer Screening

Uri Ladabaum et al.

GASTROENTEROLOGY (2020)

Review Engineering, Environmental

Toxicity of different types of quantum dots to mammalian cells in vitro: An update review

Na Liu et al.

JOURNAL OF HAZARDOUS MATERIALS (2020)

Article Nanoscience & Nanotechnology

Future of health diagnostics

Chwee Teck Lim

Review Cardiac & Cardiovascular Systems

Artificial Intelligence in Cardiovascular Imaging JACC State-of-the-Art Review

Damini Dey et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2019)

Article Engineering, Biomedical

Ultrasensitive detection of circulating exosomes with a 3D-nanopatterned microfluidic chip

Peng Zhang et al.

NATURE BIOMEDICAL ENGINEERING (2019)

Article Engineering, Biomedical

Macrophage-derived exosome-mimetic hybrid vesicles for tumor targeted drug delivery

Sagar Rayamajhi et al.

ACTA BIOMATERIALIA (2019)

Review Nanoscience & Nanotechnology

Quantum dots from microfluidics for nanomedical application

Feika Bian et al.

WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY (2019)

Article Multidisciplinary Sciences

SORLA regulates endosomal trafficking and oncogenic fitness of HER2

Mika Pietila et al.

NATURE COMMUNICATIONS (2019)

Review Immunology

Exosome-Induced Regulation in Inflammatory Bowel Disease

Huiting Zhang et al.

FRONTIERS IN IMMUNOLOGY (2019)

Review Chemistry, Analytical

Nanoparticle-based surface assisted laser desorption ionization mass spectrometry: a review

Hani Nasser Abdelhamid

MICROCHIMICA ACTA (2019)

Article Oncology

Artificial intelligence in digital pathology - new tools for diagnosis and precision oncology

Kaustav Bera et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2019)

Article Gastroenterology & Hepatology

World Endoscopy Organization Consensus Statements on Post-Colonoscopy and Post-Imaging Colorectal Cancer

Matthew D. Rutter et al.

GASTROENTEROLOGY (2018)

Review Gastroenterology & Hepatology

Bowel preparation quality scales for colonoscopy

David Kastenberg et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2018)

Article Gastroenterology & Hepatology

Global patterns and trends in colorectal cancer incidence and mortality

Melina Arnold et al.

Article Medical Laboratory Technology

Combination of preoperative NLR, PLR and CEA could increase the diagnostic efficacy for I-III stage CRC

Hong-Xin Peng et al.

JOURNAL OF CLINICAL LABORATORY ANALYSIS (2017)

Article Oncology

Cancer Susceptibility Gene Mutations in Individuals With Colorectal Cancer

Matthew B. Yurgelun et al.

JOURNAL OF CLINICAL ONCOLOGY (2017)

Review Medicine, Research & Experimental

Predictive and prognostic biomarkers in colorectal cancer: A systematic review of recent advances and challenges

Vishal Das et al.

BIOMEDICINE & PHARMACOTHERAPY (2017)

Article Acoustics

ULTRASOUND IMAGE DISCRIMINATION BETWEEN BENIGN AND MALIGNANT ADNEXAL MASSES BASED ON A NEURAL NETWORK APPROACH

Veronica Aramendia-Vidaurreta et al.

ULTRASOUND IN MEDICINE AND BIOLOGY (2016)

Article Multidisciplinary Sciences

Glypican-1 identifies cancer exosomes and detects early pancreatic cancer

Sonia A. Melo et al.

NATURE (2015)

Review Neurosciences

The Role of SORL1 in Alzheimer's Disease

Rui-Hua Yin et al.

MOLECULAR NEUROBIOLOGY (2015)

Review Multidisciplinary Sciences

The present and future role of microfluidics in biomedical research

Eric K. Sackmann et al.

NATURE (2014)

Review Nanoscience & Nanotechnology

Drug delivery and nanoparticles: Applications and hazards

Wim H. De Jong et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2008)