Exercise-induced microbial changes in preventing type 2 diabetes

The metabolic benefits associated with long-term physical activity are well appreciated and growing evidence suggests that it involves the gut microbiota. Here we re-evaluated the link between exercise-induced microbial changes and those associated with prediabetes and diabetes. We found that the relative abundances of substantial amounts of diabetes-associated metagenomic species associated negatively with physical fitness in a Chinese athlete students cohort. We additionally showed that those microbial changes correlated more with handgrip strength, a simple but valuable biomarker suggestive of the diabetes states, than maximum oxygen intake, one of the key surrogates for endurance training. Moreover, the causal relationships among exercise, risks for diabetes, and gut microbiota were explored based on mediation analysis. We propose that the protective roles of exercise against type 2 diabetes are mediated, at least partly, by the gut microbiota.

Automated summary

The study found that there is a link between exercise-induced changes in gut microbiota and the risk of prediabetes and diabetes. The relative abundances of diabetes-associated metagenomic species were negatively correlated with physical fitness in a Chinese athlete students cohort. The findings suggest that the protective effects of exercise against type 2 diabetes may be mediated by the gut microbiota.