Engineered skin bacteria induce antitumor T cell responses against melanoma

Certain bacterial colonists induce a highly specific T cell response. A hallmark of this encounter is that adaptive immunity develops preemptively, in the absence of an infection. However, the functional properties of colonist-induced T cells are not well defined, limiting our ability to understand anticommensal immunity and harness it therapeutically. We addressed both challenges by engineering the skin bacterium Staphylococcus epidermidis to express tumor antigens anchored to secreted or cell-surface proteins. Upon colonization, engineered S. epidermidis elicits tumor-specific T cells that circulate, infiltrate local and metastatic lesions, and exert cytotoxic activity. Thus, the immune response to a skin colonist can promote cellular immunity at a distal site and can be redirected against a target of therapeutic interest by expressing a target-derived antigen in a commensal.

Automated summary

Certain bacterial colonists induce a specific T cell response, even in the absence of infection. By engineering a skin bacterium to express tumor antigens, researchers were able to elicit tumor-specific T cells that infiltrate lesions and possess cytotoxic activity. This reveals the potential for commensal bacteria to be harnessed therapeutically for targeted immune responses.