Comment on Human TKTL1 implies greater neurogenesis in frontal neocortex of modern humans than Neanderthals

Article Psychology, Developmental

Layer-Specific Changes in the Prefrontal Glia/Neuron Ratio Characterizes Patches of Gene Expression Disorganization in Children with Autism

Livia Nascimento Rabelo et al.

Summary: This study investigated the changes in glia/neuron ratios (GNR) in patches of the dorsolateral prefrontal cortex (DL-PFC) of children with autism spectrum disorder (ASD). The analysis of high-resolution digital images of postmortem human brains revealed a reduced GNR in the ASD DL-PFC overall, and a lower GNR in layers II-III compared to layers V-VI within the patches. These findings provide new insights into the altered neurodevelopmental programs in ASD.

JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS (2023)

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Article Multidisciplinary Sciences

Human TKTL1 implies greater neurogenesis in frontal neocortex of modern humans than Neanderthals

Anneline Pinson et al.

Summary: This study found that the modern human variant hTKTL1, but not the Neanderthal variant, can increase the abundance of bRG without affecting bIPs, thereby affecting the generation of neocortical neurons. This indicates differences in neocortical neurogenesis between modern humans and Neanderthals.

SCIENCE (2022)

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Article Multidisciplinary Sciences

Reintroduction of the archaic variant of NOVA1 in cortical organoids alters neurodevelopment

Cleber A. Trujillo et al.

Summary: The evolutionarily conserved splicing regulator NOVA1 plays a crucial role in neural development and function, with a protein-coding difference between modern humans and Neanderthals. Reintroducing the archaic allele of NOVA1 into human induced pluripotent cells resulted in slower neural development and increased surface complexity, reflecting potential functional consequences for human evolution.

SCIENCE (2021)

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Editorial Material Genetics & Heredity