4.4 Article

Lower levels of cortical [3H]pirenzepine binding to postmortem tissue defines a sub-group of older people with schizophrenia with less severe cognitive deficits

Related references

Note: Only part of the references are listed.
Article Radiology, Nuclear Medicine & Medical Imaging

PET Imaging of Cholinergic Neurotransmission in Neurodegenerative Disorders

Solveig Tiepolt et al.

Summary: This review summarizes the current knowledge on positron emission tomography (PET) imaging of cholinergic neurotransmission in neurodegenerative diseases. Research suggests that PET imaging of cholinergic receptors, transporters, enzymes, and acetylcholinesterase can provide valuable insights into the diagnosis, monitoring, and treatment of neurodegenerative diseases.

JOURNAL OF NUCLEAR MEDICINE (2022)

Article Psychiatry

Evidence that a working memory cognitive phenotype within schizophrenia has a unique underlying biology

Brian Dean et al.

Summary: Studying the working memory deficit phenotype within the syndrome of schizophrenia and its gene expression changes is significant for understanding the molecular pathology of the disorder and developing personalized medicine.

PSYCHIATRY RESEARCH (2022)

Article Clinical Neurology

PET Imaging of brain muscarinic receptors with 18F-Fluorobenzyl-Dexetimide: A first in human study

Christopher C. Rowe et al.

Summary: M1 and M4 muscarinic receptor (mAChR) agonists are being developed for the treatment of schizophrenia, Alzheimer's, and Parkinson's disease. This study used F-18-Fluorobenzyl-Dexetimide (FDEX) for PET imaging in humans, revealing good brain entry of the tracer and irreversible distribution kinetics over four hours in regions with high mAChR. Regional binding consistency was observed, with little variance between subjects, and a strong correlation between SUVR values and Ki values.

PSYCHIATRY RESEARCH-NEUROIMAGING (2021)

Article Medicine, General & Internal

Muscarinic Cholinergic Receptor Agonist and Peripheral Antagonist for Schizophrenia

Stephen K. Brannan et al.

Summary: The study showed that combined use of xanomeline and trospium in patients with schizophrenia led to a significant improvement in symptoms but was associated with cholinergic and anticholinergic adverse events, highlighting the need for larger and longer trials to determine efficacy and safety.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

Article Behavioral Sciences

Loss of Basal Forebrain Cholinergic Neurons Following Adolescent Binge Ethanol Exposure: Recovery With the Cholinesterase Inhibitor Galantamine

Fulton T. Crews et al.

Summary: Adolescent binge drinking can lead to persistent loss of cholinergic neurons in the adult basal forebrain, and treatment with the cholinesterase inhibitor galantamine may help recover this loss.

FRONTIERS IN BEHAVIORAL NEUROSCIENCE (2021)

Article Psychiatry

Age-Specific Prevalence and Incidence of Dementia Diagnoses Among Older US Adults With Schizophrenia

T. Scott Stroup et al.

Summary: This study found that older adults with schizophrenia had an increased risk of dementia diagnosis across different age groups compared to those without serious mental illness, possibly due to cognitive and functional decline associated with schizophrenia or other factors contributing to dementia. The high rates of dementia in adults with schizophrenia have implications for illness trajectory, treatment, and service utilization.

JAMA PSYCHIATRY (2021)

Article Neurosciences

Adolescent administration of Δ9-THC decreases the expression and function of muscarinic-1 receptors in prelimbic prefrontal cortical neurons of adult male mice

Miguel Garzon et al.

Summary: Long-term cannabis use during adolescence can have harmful effects on the brain, mainly due to the impact of marijuana components on the brain. This study found that the action of Delta 9-THC in the PL-PFC can affect the distribution and function of M1R, leading to cortical dysfunction.

IBRO NEUROSCIENCE REPORTS (2021)

Article Psychiatry

Changes in cortical gene expression in the muscarinic M1 receptor knockout mouse: potential relevance to schizophrenia, Alzheimer's disease and cognition

Brian Dean et al.

Summary: Studies show low levels of cortical muscarinic M1 receptors (CHRM1) in schizophrenia patients, affecting gene expression. Changes in cortical gene expression in Chrm1(-/-) mice are linked to schizophrenia pathology and Alzheimer's disease. Additionally, genes affected by CHRM1-mediated changes in gene expression are associated with cognitive ability in humans.

NPJ SCHIZOPHRENIA (2021)

Review Neurosciences

The influence of COMT rs4680 on functional connectivity in healthy adults: A systematic review

Kim A. Morris et al.

EUROPEAN JOURNAL OF NEUROSCIENCE (2020)

Article Clinical Neurology

Widespread Changes in Positive Allosteric Modulation of the Muscarinic M1 Receptor in Some Participants With Schizophrenia

Shaun Hopper et al.

INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY (2019)

Article Genetics & Heredity

COMT genotype is associated with differential expression of muscarinic M1 receptors in human cortex

Brian Dean et al.

AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS (2016)

Article Pharmacology & Pharmacy

The Cholinergic System: An Emerging Drug Target for Schizophrenia

Andrew Gibbons et al.

CURRENT PHARMACEUTICAL DESIGN (2016)

Article Clinical Neurology

Widespread decreases in cortical muscarinic receptors in a subset of people with schizophrenia

Andrew Stuart Gibbons et al.

INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY (2013)

Article Pathology

Loss of Muscarinic M1 Receptor Exacerbates Alzheimer's Disease-Like Pathology and Cognitive Decline

Rodrigo Medeiros et al.

AMERICAN JOURNAL OF PATHOLOGY (2011)

Editorial Material Biochemistry & Molecular Biology

Pyramidal neurons

John M. Bekkers

CURRENT BIOLOGY (2011)

Article Biochemistry & Molecular Biology

Decreased cortical muscarinic receptors define a subgroup of subjects with schizophrenia

E. Scarr et al.

MOLECULAR PSYCHIATRY (2009)

Editorial Material Psychiatry

Accelerating new knowledge in schizophrenia

Carol A. Tamminga

AMERICAN JOURNAL OF PSYCHIATRY (2008)

Article Psychiatry

Selective muscarinic receptor agonist xanomeline as a novel treatment approach for schizophrenia

Anantha Shekhar et al.

AMERICAN JOURNAL OF PSYCHIATRY (2008)

Article Biochemistry & Molecular Biology

Muscarinic receptors: do they have a role in the pathology and treatment of schizophrenia?

Elizabeth Scarr et al.

JOURNAL OF NEUROCHEMISTRY (2008)

Article Behavioral Sciences

Planning, decision-making and the COMT rs4818 polymorphism in healthy males

Panos Roussos et al.

NEUROPSYCHOLOGIA (2008)

Article Neurosciences

Human postmortem tissue: What quality markers matter?

Ana D. Stan et al.

BRAIN RESEARCH (2006)

Article Neurosciences

Increased cannabinoid receptor density in the posterior cingulate cortex in schizophrenia

Kelly A. Newell et al.

EXPERIMENTAL BRAIN RESEARCH (2006)

Article Medicine, Research & Experimental

No change in cortical muscarinic M2, M3 receptors or [35S]GTPγS binding in schizophrenia

E Scarr et al.

LIFE SCIENCES (2006)

Review Medicine, Research & Experimental

Muscarinic receptors in schizophrenia

B Dean et al.

CURRENT MOLECULAR MEDICINE (2003)

Article Genetics & Heredity

Reduced expression of the muscarinic 1 receptor cortical subtype in schizophrenia

D Mancama et al.

AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS (2003)

Article Psychiatry

In vivo determination of muscarinic acetylcholine receptor availability in schizophrenia

TJ Raedler et al.

AMERICAN JOURNAL OF PSYCHIATRY (2003)

Article Biochemistry & Molecular Biology

Decreased muscarinic(1) receptors in the dorsolateral prefrontal cortex of subjects with schizophrenia

B Dean et al.

MOLECULAR PSYCHIATRY (2002)

Review Neurosciences

A neurobiological basis for substance abuse comorbidity in schizophrenia

RA Chambers et al.

BIOLOGICAL PSYCHIATRY (2001)

Article Biochemistry & Molecular Biology

Laminar distribution of nicotinic receptor subtypes in cortical regions in schizophrenia

A Marutle et al.

JOURNAL OF CHEMICAL NEUROANATOMY (2001)

Article Medicine, Research & Experimental

Elucidating the role of muscarinic receptors in psychosis

CC Felder et al.

LIFE SCIENCES (2001)

Article Pharmacology & Pharmacy

Smoking and schizophrenia: abnormal nicotinic receptor expression

S Leonard et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2000)