Solvent-Free Reaction of 3,6-Diaryl-1,2,4-triazine-5-carbonitriles with 2-Amino-4-aryloxazoles

Solvent-free reaction of 3,6-diaryl-1,2,4-triazine-5-carbonitriles with 2-amino-4-aryloxazoles was studied. In this case, the formation of 3- and 4-aryl-substituted pyridines (two isomeric products) in yields up to 20 and 27%, respectively, was found. This result is different from that for the reaction of 3-(2-pyridyl)-1,2,4-triazine-5-carbonitriles with these substrates. Thus, in this case, 2-amino-4-aryloxazoles act as synthetic analogues of arylacetylenes.

Automated summary

The solvent-free reaction between 3,6-diaryl-1,2,4-triazine-5-carbonitriles and 2-amino-4-aryloxazoles was investigated, leading to the formation of 3- and 4-aryl-substituted pyridines in yields up to 20% and 27%, respectively. This reaction differs from the reaction of 3-(2-pyridyl)-1,2,4-triazine-5-carbonitriles with the same substrates. Therefore, 2-amino-4-aryloxazoles function as synthetic analogues of arylacetylenes in this case.