4.7 Article

Efgartigimod restores muscle function in a humanized mouse model of immune-mediated necrotizing myopathy

Related references

Note: Only part of the references are listed.
Article Pharmacology & Pharmacy

Efgartigimod: First Approval

Young-A Heo

Summary: Efgartigimod is a novel drug developed by argenx for the treatment of autoimmune diseases, including myasthenia gravis. It received its first approval in the USA in 2021 and is currently being evaluated and registered in other countries. Numerous clinical studies are also investigating the use of Efgartigimod in various other autoimmune diseases.

DRUGS (2022)

Article Biochemistry & Molecular Biology

Prevention of Anti-HMGCR Immune-Mediated Necrotising Myopathy by C5 Complement Inhibition in a Humanised Mouse Model

Sarah Julien et al.

Summary: In a humanized mouse model of IMNM, early administration of zilucoplan was found to prevent the onset of myopathy and significantly inhibit complement activation.

BIOMEDICINES (2022)

Review Rheumatology

Immune-mediated necrotizing myopathy: clinical features and pathogenesis

Yves Allenbach et al.

NATURE REVIEWS RHEUMATOLOGY (2020)

Article Medicine, Research & Experimental

Neonatal Fc receptor antagonist efgartigimod safely and sustainably reduces IgGs in humans

Peter Ulrichts et al.

JOURNAL OF CLINICAL INVESTIGATION (2018)

Article Clinical Neurology

Clinical Features and Treatment Outcomes of Necrotizing Autoimmune Myopathy

Charles D. Kassardjian et al.

JAMA NEUROLOGY (2015)

Review Immunology

FcRn: the neonatal Fc receptor comes of age

Derry C. Roopenian et al.

NATURE REVIEWS IMMUNOLOGY (2007)