Journal
REVIEWS IN MEDICAL VIROLOGY
Volume 33, Issue 2, Pages -Publisher
WILEY
DOI: 10.1002/rmv.2427
Keywords
COVID-19; flavonol; quercetin; SARS-CoV-2
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Currently approved therapies for COVID-19 have limitations such as low availability, high costs, and the need for trained medical personnel in a hospital setting. Quercetin, a cheap and accessible option, was evaluated in a meta-analysis to assess its effect on COVID-19 patients. The results showed that quercetin reduced the risk of intensive care unit admission and hospitalization but did not decrease the risk of all-cause mortality and the rate of no recovery. Further large-scale randomized controlled trials are needed to confirm these findings.
Currently approved therapies for COVID-19 are mostly limited by their low availability, high costs or the requirement of parenteral administration by trained medical personnel in an in-hospital setting. Quercetin is a cheap and easily accessible therapeutic option for COVID-19 patients. However, it has not been evaluated in a systematic review until now. We aimed to conduct a meta-analysis to assess the effect of quercetin on clinical outcomes in COVID-19 patients. Various databases including PubMed, the Cochrane Library and Embase were searched from inception until 5 October 2022 and results from six randomized controlled trials (RCTs) were pooled using a random-effects model. All analyses were conducted using RevMan 5.4 with odds ratio (OR) as the effect measure. Quercetin decreased the risk of intensive care unit admission (OR = 0.31; 95% confidence interval (CI) 0.10-0.99) and the incidence of hospitalisation (OR = 0.25; 95% CI 0.10-0.62) but did not decrease the risk of all-cause mortality and the rate of no recovery. Quercetin may be of benefit in COVID-19 patients, especially if administered in its phytosome formulation which greatly enhances its bioavailability but large-scale RCTs are needed to confirm these findings.
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