A novel, ecofriendly 1H-1,2,4-triazole-3-thiol-functionalized Fe3O4@SiO2 magnetic nano-catalyst for the synthesis of 2H-indazolo[2,1-b] phthalazine-trione and triazolo[1,2-a]indazole-trione derivatives

The synthesis of 2H-indazolo[2,1-b] phthalazine-triones and triazolo[1,2-a]indazole-triones catalyzed by 1H-1,2,4-triazole-3-thiol-functionalized core-shell Fe3O4@SiO2 magnetic nanocomposite in one-pot three-component reactions under solvent-free conditions is introduced. The catalyst was fabricated through a four-step protocol and was characterized by different techniques. The catalytic activity of nano-catalyst to generate some products was assessed. The excellent yields for all products were obtained when 15 mg of the as-prepared magnetic nanocomposite was utilized in one-pot solvent-free three-component reactions at 100 degrees C. The investigation of the reusability of the catalyst showed the stability of 92% after five runs. The simplicity of use and easy separation are the additional advantages of the proposed procedure.

Automated summary

The synthesis of 2H-indazolo[2,1-b] phthalazine-triones and triazolo[1,2-a]indazole-triones through one-pot three-component reactions under solvent-free conditions using a 1H-1,2,4-triazole-3-thiol-functionalized core-shell Fe3O4@SiO2 magnetic nanocomposite as catalyst is presented. The catalyst was developed through a four-step protocol and characterized using various techniques. The catalytic activity of the nano-catalyst was evaluated, showing excellent yields for all products. The catalyst demonstrated a stability of 92% after five runs, with the additional advantages of simplicity of use and easy separation.