☆ 4.5 Article

Exploratory metabolomic analysis based on UHPLC-Q-TOF-MS/MS to study hypoxia-reoxygenation energy metabolic alterations in HK-2 cells

RENAL FAILURE (2023)

Related references

Note: Only part of the references are listed.

Review Chemistry, Medicinal

Metabolomics as a tool for the early diagnosis and prognosis of diabetic kidney disease

Pedro R. Pereira et al.

Summary: Diabetic kidney disease is a common complication of diabetes mellitus and a leading cause of end-stage renal disease. Current methods have limitations in detecting non-albuminuric phenotypes of diabetic nephropathy, but metabolomics offers a promising tool for more accurate diagnosis and prediction.

MEDICINAL RESEARCH REVIEWS (2022)

Add to Collection

Review Endocrinology & Metabolism

Transition of acute kidney injury to chronic kidney disease: role of metabolic reprogramming

Zijing Zhu et al.

Summary: Acute kidney injury (AKI) is a global public health concern, and the transition from AKI to chronic kidney disease (CKD) is complex and involves multiple mechanisms, with the metabolic reprogramming of renal tubular epithelial cells (TECs) playing a crucial role.

METABOLISM-CLINICAL AND EXPERIMENTAL (2022)

Add to Collection

Review Urology & Nephrology

Immunometabolic rewiring of tubular epithelial cells in kidney disease

Sanne van der Rijt et al.

Summary: Kidney tubular epithelial cells play a crucial role in the response to kidney injury and repair, and their metabolic abnormalities may contribute to kidney disease. Receptors of the innate immune system regulate the metabolic processes of these cells, and the interplay between immunometabolism and kidney health should be taken into consideration.

NATURE REVIEWS NEPHROLOGY (2022)

Add to Collection

Article Critical Care Medicine

The Warburg Effect Promotes Mitochondrial Injury Regulated by Uncoupling Protein-2 in Septic Acute Kidney Injury

Ran Ji et al.

Summary: The study demonstrates that aerobic glycolysis is enhanced in septic tubular epithelial cells and inhibition of glycolysis can partially restore mitochondrial function. Knockdown of UCP2 results in increased aerobic glycolysis and mitochondrial injury. Targeting aerobic glycolysis may be important in the treatment of septic acute kidney injury.

SHOCK (2021)

Add to Collection

Article Oncology

The dysregulation of metabolic pathways and induction of the pentose phosphate pathway in renal ischaemia-reperfusion injury

Angelique M. L. Scantlebery et al.

Summary: The study identified significant accumulation of cholesterol, phospholipids, and sphingolipids in renal tissue following ischemia-reperfusion injury. Metabolic pathways related to lipid metabolism were found to be downregulated, except for the pentose phosphate pathway which was upregulated 24 hours after injury.

JOURNAL OF PATHOLOGY (2021)

Add to Collection

Review Medicine, General & Internal

Tubular Cell Glucose Metabolism Shift During Acute and Chronic Injuries

Anna Faivre et al.

Summary: Acute and chronic kidney disease result in significant healthcare costs worldwide. Kidney metabolism undergoes profound changes during injury, potentially affecting fibrosis progression. Glucose metabolism may play a crucial role in both acute and chronic phases of renal disease.

FRONTIERS IN MEDICINE (2021)

Add to Collection

Article Multidisciplinary Sciences

Single-nuclear transcriptomics reveals diversity of proximal tubule cell states in a dynamic response to acute kidney injury

Louisa M. S. Gerhardt et al.

Summary: The study found that even mild to moderate ischemia-reperfusion injury can cause lasting damage, spreading from the cortico-medullary boundary (CMB) to cortical regions, and the remaining failed-repair PTCs may be triggers for chronic disease progression.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

Add to Collection

Article Multidisciplinary Sciences

Krappel-like factor 6-mediated loss of BCAA catabolism contributes to kidney injury in mice and humans

Sian E. Piret et al.

Summary: The altered cellular metabolism in kidney proximal tubule (PT) cells, particularly involving the transcription factor Krappel-like factor 6 (KLF6), plays a critical role in acute kidney injury (AKI) and kidney fibrosis. Targeting KLF6-mediated suppression of branched-chain amino acid (BCAA) catabolism may serve as a key therapeutic target in AKI and kidney fibrosis, as shown by protective effects in mice and inverse correlations in human chronic kidney disease patients.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

Add to Collection

Article Multidisciplinary Sciences

Tyrosine and Tryptophan vibrational bands as markers of kidney injury: a renocardiac syndrome induced by renal ischemia and reperfusion study

Gabrielle Nepomuceno et al.

Summary: Renal ischemia and reperfusion-induced changes in molecular markers, such as cysteine/cystine, fatty acids, Collagen, Tyrosine, and Tryptophan, were detected using FT-Raman spectroscopy, showing potential for predicting progression of acute to chronic kidney injury and mortality in cardiovascular diseases. Monitoring Tyrosine and Tryptophan bands at specific wave numbers proved to be a viable and advantageous method for predicting fatality in cardiovascular diseases using the real-time, multiplexing, and minimally invasive advantages of FT-Raman spectroscopy.

SCIENTIFIC REPORTS (2021)

Add to Collection

Article Biochemistry & Molecular Biology

Dietary omega-3 PUFA improved tubular function after ischemia induced acute kidney injury in mice but did not attenuate impairment of renal function

Katharina M. Rund et al.

PROSTAGLANDINS & OTHER LIPID MEDIATORS (2020)

Add to Collection

Review Biotechnology & Applied Microbiology

Omega-3 Polyunsaturated Fatty Acid Supplementation for Reducing Muscle Soreness after Eccentric Exercise: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Zheng-tao Lv et al.

BIOMED RESEARCH INTERNATIONAL (2020)

Add to Collection

Article Multidisciplinary Sciences

Effect of sodium (S)-2-hydroxyglutarate in male, and succinic acid in female Wistar rats against renal ischemia-reperfusion injury, suggesting a role of the HIF-1 pathway

Eduardo Cienfuegos-Pecina et al.

PEERJ (2020)

Add to Collection

Article Multidisciplinary Sciences

Enhancer and super-enhancer dynamics in repair after ischemic acute kidney injury

Julia Wilflingseder et al.

NATURE COMMUNICATIONS (2020)

Add to Collection

Review Medicine, General & Internal

Defective Mitochondrial Fatty Acid Oxidation and Lipotoxicity in Kidney Diseases

Hee-Seong Jang et al.

FRONTIERS IN MEDICINE (2020)

Add to Collection

Review Medicine, General & Internal

Acute kidney injury

Claudio Ronco et al.

LANCET (2019)

Add to Collection

Article Multidisciplinary Sciences

Metabolic reprogramming by the S-nitroso-CoA reductase system protects against kidney injury

Hua-Lin Zhou et al.

NATURE (2019)

Add to Collection

Article Physiology

Identification of novel metabolomic biomarkers in an experimental model of septic acute kidney injury

Jose L. Izquierdo-Garcia et al.

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2019)

Add to Collection

Review Chemistry, Analytical

Current and future perspectives of functional metabolomics in disease studies-A review

Min Yan et al.

ANALYTICA CHIMICA ACTA (2018)

Add to Collection

Review Urology & Nephrology

Proteomics and Metabolomics for AKI Diagnosis

David Marx et al.

SEMINARS IN NEPHROLOGY (2018)

Add to Collection

Review Urology & Nephrology

Global epidemiology and outcomes of acute kidney injury

Eric A. J. Hoste et al.

NATURE REVIEWS NEPHROLOGY (2018)

Add to Collection

Article Physiology

What we need to know about lipid-associated injury in case of renal ischemia-reperfusion

Pauline Erpicum et al.

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2018)

Add to Collection

Review Urology & Nephrology

Mitochondrial energetics in the kidney

Pallavi Bhargava et al.

NATURE REVIEWS NEPHROLOGY (2017)

Add to Collection

Article Multidisciplinary Sciences

D-serine, a novel uremic toxin, induces senescence in human renal tubular cells via GCN2 activation

Akira Okada et al.

SCIENTIFIC REPORTS (2017)

Add to Collection

Article Urology & Nephrology

Inflammation in AKI: Current Understanding, Key Questions, and Knowledge Gaps

Hamid Rabb et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2016)

Add to Collection

Review Transplantation

Mitochondria: a therapeutic target in acute kidney injury

Yu Ishimoto et al.

NEPHROLOGY DIALYSIS TRANSPLANTATION (2016)

Add to Collection

Article Medicine, Research & Experimental

Protective effect of green tea extract against proline-induced oxidative damage in the rat kidney

Debora Delwing-Dal Magro et al.

BIOMEDICINE & PHARMACOTHERAPY (2016)

Add to Collection

Article Urology & Nephrology

Mitochondrial Pathology and Glycolytic Shift during Proximal Tubule Atrophy after Ischemic AKI

Rongpei Lan et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2016)

Add to Collection

Article Multidisciplinary Sciences

S-2-hydroxyglutarate regulates CD8+ T-lymphocyte fate

Petros A. Tyrakis et al.

NATURE (2016)

Add to Collection

Article Multidisciplinary Sciences

Nuclear Magnetic Resonance Metabolomic Profiling of Mouse Kidney, Urine and Serum Following Renal Ischemia/Reperfusion Injury

Francois Jouret et al.

PLOS ONE (2016)

Add to Collection

Article Physiology

Early lipid changes in acute kidney injury using SWATH lipidomics coupled with MALDI tissue imaging

Sangeetha Rao et al.

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2016)

Add to Collection

Article Biochemistry & Molecular Biology

Defective fatty acid oxidation in renal tubular epithelial cells has a key role in kidney fibrosis development

Hyun Mi Kang et al.

NATURE MEDICINE (2015)

Add to Collection

Review Medicine, General & Internal

Alteration of fatty acid oxidation in tubular epithelial cells: from acute kidney injury to renal fibrogenesis

Noemie Simon et al.

FRONTIERS IN MEDICINE (2015)

Add to Collection

Article Urology & Nephrology

Renal Cortical Pyruvate Depletion during AKI

Richard A. Zager et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2014)

Add to Collection

Article Multidisciplinary Sciences

Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS

Edward T. Chouchani et al.

NATURE (2014)

Add to Collection

Article Physiology

Renal cortical hexokinase and pentose phosphate pathway activation through the EGFR/Akt signaling pathway in endotoxin-induced acute kidney injury

Joshua A. Smith et al.

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2014)

Add to Collection

Review Medicine, Research & Experimental

Glutamine and cancer: cell biology, physiology, and clinical opportunities

Christopher T. Hensley et al.

JOURNAL OF CLINICAL INVESTIGATION (2013)

Add to Collection

Review Critical Care Medicine

Diagnosis, evaluation, and management of acute kidney injury: a KDIGO summary (Part 1)

John A. Kellum et al.

CRITICAL CARE (2013)

Add to Collection

Article Medicine, General & Internal

Acute kidney injury

Rinaldo Bellomo et al.

LANCET (2012)

Add to Collection

Review Urology & Nephrology

Metabolomics in the study of kidney diseases

Robert H. Weiss et al.

NATURE REVIEWS NEPHROLOGY (2012)

Add to Collection

Article Physiology

Adverse effects of α-ketoglutarate/malate in a rat model of acute kidney injury

Anja Bienholz et al.

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2012)

Add to Collection

Review Cardiac & Cardiovascular Systems

Metabolic fingerprint of ischaemic cardioprotection: importance of the malate-aspartate shuttle

Torsten Toftegaard Nielsen et al.

CARDIOVASCULAR RESEARCH (2011)

Add to Collection

Review Pharmacology & Pharmacy

Cell culture metabolomics: applications and future directions

Miroslava Cuperlovic-Culf et al.

DRUG DISCOVERY TODAY (2010)

Add to Collection

Review Urology & Nephrology

The Role of Tubulointerstitial Inflammation in the Progression of Chronic Renal Failure

Bernardo Rodriguez-Iturbe et al.

NEPHRON CLINICAL PRACTICE (2010)

Add to Collection

Article Biochemistry & Molecular Biology

Dietary docosahexaenoic and eicosapentaenoic acid: Emerging mediators of inflammation

Robert S. Chapkin et al.

PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS (2009)

Add to Collection

Review Cell Biology

The biology of cancer: Metabolic reprogramming fuels cell growth and proliferation

Ralph J. DeBerardinis et al.

CELL METABOLISM (2008)

Add to Collection

Article Urology & Nephrology

Triglyceride accumulation in injured renal tubular cells: Alterations in both synthetic and catabolic pathways

ACM Johnson et al.

KIDNEY INTERNATIONAL (2005)

Add to Collection

Article Nutrition & Dietetics

Renal arginine metabolism

ME Brosnan et al.

JOURNAL OF NUTRITION (2004)

Add to Collection

Article Urology & Nephrology

The flux of arginine after ischemia-reperfusion in the rat kidney

HA Prins et al.

KIDNEY INTERNATIONAL (2002)

Add to Collection

© Peeref 2019-2024. All rights reserved.