4.5 Article

LncTUG1 ameliorates renal tubular fibrosis in experimental diabetic nephropathy through the miR-145-5p/dual-specificity phosphatase 6 axis

Related references

Note: Only part of the references are listed.
Article Biochemistry & Molecular Biology

Can miR-145-5p be used as a marker in diabetic patients?

Seyedeh Zahra Shahrokhi et al.

Summary: In this study, the expression level of plasma miR-145-5p was evaluated in diabetics and pre-diabetics, and it was found to be a potential biomarker for the diagnosis of T2DM.

ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY (2022)

Article Plant Sciences

Total coumarin derivates from Hydrangea paniculata attenuate renal injuries in cationized-BSA induced membranous nephropathy by inhibiting complement activation and interleukin 10-mediated interstitial fibrosis

Weida Wang et al.

Summary: The study evaluated the renal protective effect of Hydrangea Paniculata, Sieb (HP) in an experimental model of membranous nephritis (MN) and explored its underlying mechanisms. HP administration improved renal function, reduced dyslipidemia and histopathological injuries. mRNA sequencing indicated anti-inflammation and anti-fibrosis effects of HP, possibly through down-regulating the complement activation and PI3K-AKT pathways. Pharmacokinetic studies identified skimmin and 7-hydoxycoumarin (7-HC) as major compounds in HP. Inflammatory macrophage IL10 production was inhibited by skimmin and 7-HC through blocking PI3K-AKT and NF Kappa B signaling pathways. HP protected tubulointerstitium from complement attack by reducing C3 self-production and auto-cleavage in tubular cells.

PHYTOMEDICINE (2022)

Review Chemistry, Multidisciplinary

Druggability of lipid metabolism modulation against renal fibrosis

Yuan-yuan Chen et al.

Summary: Renal fibrosis, a common pathological process in chronic kidney disease leading to kidney failure, lacks effective drugs for treatment. Dysfunctional lipid metabolism exacerbates chronic kidney disease and fibrosis, while restoring fatty acid oxidation may alleviate renal fibrosis.

ACTA PHARMACOLOGICA SINICA (2022)

Review Pharmacology & Pharmacy

Long non-coding RNAs: From disease code to drug role

Yuanyuan Chen et al.

Summary: Extensive studies have shown that long non-coding RNAs (lncRNAs) play crucial roles in physiological processes and are closely linked to various diseases. Using lncRNAs as biomarkers or intervention targets can provide new perspectives for disease diagnosis and treatment. Research is shifting towards utilizing lncRNAs as pharmacological targets, with a focus on preclinical research and clinical trial progress.

ACTA PHARMACEUTICA SINICA B (2021)

Article Medicine, Research & Experimental

Loganin alleviates macrophage infiltration and activation by inhibiting the MCP-1/CCR2 axis in diabetic nephropathy

Qiu Du et al.

Summary: Loganin protects the kidney from damage in diabetic nephropathy by inhibiting macrophage infiltration and activation. It regulates the RAGE/MCP-1/CCR2 signaling pathway, affecting macrophage phenotypic transformation and expression of inflammatory factors.

LIFE SCIENCES (2021)

Review Oncology

Effects of metabolic memory on inflammation and fibrosis associated with diabetic kidney disease: an epigenetic perspective

Wen Zheng et al.

Summary: Diabetic kidney disease (DKD) is a common complication of diabetes, influenced by genetic and environmental factors. Epigenetic modifications play a crucial role in DKD development and may offer new therapeutic avenues for intervention.

CLINICAL EPIGENETICS (2021)

Article Oncology

New insight into long non-coding RNAs associated with bone metastasis of breast cancer based on an integrated analysis

Yu Zhang et al.

Summary: This study identified four LncRNA-mRNA pairs, including LOC641518-LEF1, which may play a central role in breast cancer bone metastasis.

CANCER CELL INTERNATIONAL (2021)

Review Biochemistry & Molecular Biology

TGF-β Signaling: From Tissue Fibrosis to Tumor Microenvironment

Jeff Yat-Fai Chung et al.

Summary: TGF-beta signaling plays crucial roles in inflammatory diseases by regulating immunocytes in tissue fibrosis and accelerating tumor development in cancer. The pleiotropic nature of TGF-beta signaling in generating fibrotic TME, containing CAFs and matrix proteins, remains largely unclear, despite recent studies demonstrating its clinical implications in cancer.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Article Cell Biology

Angiotensin II-induced redox-sensitive SGLT1 and 2 expression promotes high glucose-induced endothelial cell senescence

Sonia Khemais-Benkhiat et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2020)

Article Oncology

DUSP6 protects murine podocytes from high glucose-induced inflammation and apoptosis

Liqiang Chen et al.

MOLECULAR MEDICINE REPORTS (2020)

Article Multidisciplinary Sciences

Neural transcription factor Pou4f1 promotes renal fibrosis via macrophage-myofibroblast transition

Patrick Ming-Kuen Tang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

Article Biochemistry & Molecular Biology

Downregulation of miR-145-5p elevates retinal ganglion cell survival to delay diabetic retinopathy progress by targeting FGF5

Jingjing Zhang et al.

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY (2019)

Article Biochemistry & Molecular Biology

Clopidogrel Reduces Fibronectin Accumulation and Improves Diabetes-Induced Renal Fibrosis

Zongyu Zheng et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2019)

Article Endocrinology & Metabolism

Gestational Diabetes Mellitus Regulatory Network Identifies hsa-miR-145-5p and hsa-miR-875-5p as Potential Biomarkers

Mona Zamanian Azodi et al.

INTERNATIONAL JOURNAL OF ENDOCRINOLOGY AND METABOLISM (2019)

Article Medicine, Research & Experimental

被撤回的出版物: TUG1 alleviates hypoxia injury by targeting miR-124 in H9c2 cells (Retracted article. See vol. 150, 2022)

Nianxin Jiang et al.

BIOMEDICINE & PHARMACOTHERAPY (2018)

Review Urology & Nephrology

The role of the complement system in diabetic nephropathy

Allan Flyvbjerg

NATURE REVIEWS NEPHROLOGY (2017)

Review Genetics & Heredity

Long non-coding RNAs as novel players in β cell function and type 1 diabetes

Aashiq H. Mirza et al.

HUMAN GENOMICS (2017)

Review Endocrinology & Metabolism

Intestinal Microbiota in Type 2 Diabetes and Chronic Kidney Disease

Alice Sabatino et al.

CURRENT DIABETES REPORTS (2017)

Article Medicine, Research & Experimental

Long noncoding RNA Tug1 regulates mitochondrial bioenergetics in diabetic nephropathy

Jianyin Long et al.

JOURNAL OF CLINICAL INVESTIGATION (2016)

Review Urology & Nephrology

TGF-β: the master regulator of fibrosis

Xiao-ming Meng et al.

NATURE REVIEWS NEPHROLOGY (2016)

Article Pharmacology & Pharmacy

Skimmin, a coumarin, suppresses the streptozotocin-induced diabetic nephropathy in wistar rats

Sen Zhang et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2012)

Article Urology & Nephrology

Rodent models of streptozotocin-induced diabetic nephropathy

Greg H. Tesch et al.

NEPHROLOGY (2007)

Article Biochemistry & Molecular Biology

Smad pathway is activated in the diabetic mouse kidney and Smad3 mediates TGF-β-induced fibronectin in mesangial cells

M Isono et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2002)