Journal
JOURNAL OF VIROLOGY
Volume 90, Issue 9, Pages 4838-4842Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.02994-15
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Funding
- TOP Project grant - ZonMW [91213066]
- Zoonotic Anticipation and Preparedness Initiative (ZAPI project) [115760]
- IMI
- European Commission
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Middle East respiratory syndrome coronavirus (MERS-CoV) is not efficiently transmitted between humans, but it is highly prevalent in dromedary camels. Here we report that the MERS-CoV receptor-dipeptidyl peptidase 4 (DPP4)-is expressed in the upper respiratory tract epithelium of camels but not in that of humans. Lack of DPP4 expression may be the primary cause of limited MERS-CoV replication in the human upper respiratory tract and hence restrict transmission.
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