Journal
JOURNAL OF VIROLOGY
Volume 90, Issue 9, Pages 4827-4831Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.02832-15
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Funding
- Deutsche Forschungsgemeinschaft (DFG) [FOR1202 (TP 5)]
- Deutsches Zentrum fur Infektionsforschung (DZIF) [5.807, 5.704]
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Hepatitis B virus (HBV) enters hepatocytes via its receptor, human sodium taurocholate cotransporting polypeptide (hNTCP). So far, HBV infection has been achieved only in human hepatic cells reconstituted with hNTCP and not in cells of mouse origin. Here, the first mouse liver cell line (AML12) which gains susceptibility to HBV upon hNTCP expression is described. Thus, HBV infection of receptor-expressing mouse hepatocytes does not principally require a human cofactor but can be triggered by endogenous murine determinants.
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