Nanoparticle drug delivery systems and their applications as targeted therapies for triple negative breast cancer

The therapeutic effect of highly malignant triple negative breast cancer (TNBC) is negatively affected by the formation of tumor cell resistant clone and the severe toxicity of chemotherapy drugs to normal tissues. In accordance with research findings, in the comprehensive targeted therapy of TNBC, the nano delivery system effectively suppresses and kills tumor cells on the basis of its unique targeting properties as well as the ability to co-load, deliver, and release chemotherapeutic drugs, active gene fragments and immune enhancing factors, etc. When combined with photothermal ablation therapy, the synergism and toxicity reduction effect of chemotherapy drugs, the inhibition of tumor proliferation related genes as well as activation of immune system can be achieved. Nanoparticle delivery systems present a totally new way of drug design and usage, and change the pharmacokinetic characteristics of conventional chemotherapeutic drugs with significantly reduced adverse effects of some otherwise very toxic chemodrugs via targeted delivery. In this paper, a detailed review was carried out focusing on the research progress of nanoparticle delivery system in the comprehensive targeted therapy of TNBC. We also summarize the merits, shortcomings, perspectives and future developments of nanoparticle-drug delivery systems.

Automated summary

The therapeutic effect of highly malignant triple negative breast cancer (TNBC) is negatively affected by resistant clone formation and severe toxicity. Nano delivery system effectively suppresses and kills tumor cells by targeted delivery of chemotherapeutic drugs, gene fragments, and immune enhancing factors. Combined with photothermal ablation therapy, it achieves synergism, toxicity reduction, gene inhibition, and immune system activation. These nanoparticle delivery systems revolutionize drug design and usage, reducing adverse effects of toxic chemodrugs.