Association between arginine vasopressin receptor 1A (AVPR1A) polymorphism and inequity aversion

Although numerous studies have focused on brain functions related to inequity aversion, few have examined its genetic basis. Here, we show the association between estimated inequity aversion and polymorphisms in three genes associated with human sociality. Non-student adult participants took part in five economic game experiments on different days. Disadvantageous inequity aversion (DIA) and advantageous inequity aversion (AIA) were calculated from behavioural responses using Bayesian estimation. We investigated the association between genetic polymorphisms in the oxytocin receptor (OXTR rs53576), arginine vasopressin receptor 1A (AVPR1A RS3) and opioid receptor mu 1 (OPRM1 rs1799971) and inequity aversion. Regarding AVPR1A RS3, participants with the SS genotype had higher AIA than those with the SL or LL genotypes, but no association was found for DIA. Moreover, we observed no aversion associations for OXTR rs53576 or OPRM1 rs1799971. The results suggest that AVPR1A plays an important role in aversion when one's own gain is greater than that of others. Our findings may provide a solid theoretical basis for future studies on the relationship between genetic polymorphisms and inequity aversion.

Automated summary

This study shows the association between genetic mutations in three genes associated with human sociality and individuals' aversion to inequity. The participants took part in five economic game experiments and their behavioral responses were used to calculate the level of disadvantageous inequity aversion and advantageous inequity aversion. The study found that there was an association between the AVPR1A gene mutation and advantageous inequity aversion, suggesting the important role of AVPR1A in aversion when individuals' gain is greater than that of others.