Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 120, Issue 15, Pages -Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.2211996120
Keywords
glucocorticoids; hippocampus; circadian rhythms; memory; methylprednisolone
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The coordinator of circadian biological systems is adrenal glucocorticoid secretion, which plays a role in regulating various physiological processes. However, disruption of this circadian rhythm during corticosteroid therapy can lead to memory impairment, and the underlying mechanisms are not yet fully understood. This study investigates the impact of corticosteroid treatment on the hippocampal transcriptome and synaptic plasticity in rats, revealing misalignment with natural circadian cues and resulting in memory deficits. These findings provide insights into the molecular basis of memory deficits in patients treated with long-acting synthetic corticosteroids.
coordinator of circadian biological systems is adrenal glucocorticoid secretion which exhibits a pronounced preawakening peak that regulates metabolic, immune, and cardiovascular processes, as well as mood and cognitive function. Loss of this circadian rhythm during corticosteroid therapy is often associated with memory impairment. Surprisingly, the mechanisms that underlie this deficit are not understood. In this study, in rats, we report that circadian regulation of the hippocampal transcriptome integrates crucial functional networks that link corticosteroid- inducible gene regulation to synaptic plasticity processes via an intrahippocampal circadian transcriptional clock. Further, these circadian hippocampal functions were significantly impacted by corticosteroid treatment delivered in a 5- d oral dosing treatment protocol. Rhythmic expression of the hippocampal transcriptome, as well as the circadian regulation of synaptic plasticity, was misaligned with the natural light/dark circadian- entraining cues, resulting in memory impairment in hippocampal- dependent behavior. These findings provide mechanistic insights into how the transcriptional clock machinery within the hippocampus is influenced by corticosteroid exposure, leading to adverse effects on critical hippocampal functions, as well as identifying a molecular basis for memory deficits in patients treated with long- acting synthetic corticosteroids.
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