4.8 Article

The energetics of rapid cellular mechanotransduction

Related references

Note: Only part of the references are listed.
Article Cell Biology

Tethering Piezo channels to the actin cytoskeleton for mechanogating via the cadherin-I3-catenin mechanotransduction complex

Jing Wang et al.

Summary: The mechanically activated Piezo channel is connected to the actin cytoskeleton via the cadherin-O-catenin mechanotransduction complex, enabling mechanosensitivity. Disruption of specific interactions impairs Piezo channel function.

CELL REPORTS (2022)

Article Multidisciplinary Sciences

Rapid propagation of membrane tension at retinal bipolar neuron presynaptic terminals

Carolina Gomis Perez et al.

Summary: Membrane tension gradients play a crucial role in cellular activities such as cell migration, division, phagocytosis, and exo-endocytosis. The speed at which membrane tension equilibrates can vary significantly depending on the cell type. Rapid synaptic vesicle turnover in neuronal terminals leads to quick membrane tension equilibration, while neuroendocrine adrenal chromaffin cells have slower recovery rates.

SCIENCE ADVANCES (2022)

Article Multidisciplinary Sciences

Focused ultrasound excites action potentials in mammalian peripheral neurons in part through the mechanically gated ion channel PIEZO2

Benjamin U. Hoffman et al.

Summary: This study successfully modulated the activity of peripheral neurons using targeted ultrasound stimulation and electrophysiology in mouse ex vivo skin-saphenous nerve preparations. The findings showed that high-intensity, millisecond ultrasound pulses reliably evoked action potentials in peripheral neurons, and there was a discrete range of parameters capable of exciting different types of neurons. Additionally, ultrasound stimulation could be targeted to cutaneous receptive fields or peripheral nerves, expanding the therapeutic range of ultrasound-based peripheral neuromodulation.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2022)

Article Multidisciplinary Sciences

Intrinsically disordered intracellular domains control key features of the mechanically-gated ion channel PIEZO2

Clement Verkest et al.

Summary: This study investigates how mechanical forces activate PIEZO2 through intracellular channel domains, demonstrating that PIEZO2 is a polymodal mechanosensor detecting different mechanical stimuli via various force transmission pathways.

NATURE COMMUNICATIONS (2022)

Review Physiology

Physics of mechanotransduction by Piezo ion channels

Michael Young et al.

Summary: Piezo ion channels are important sensors of mechanical forces in physiology. This review explores the forces and energies involved in their activation and modulation by chemical and physical stimuli. It also discusses the spatial clustering and functional cooperativity of Piezo ion channels, as well as the functional heterogeneity arising from their physical environment. The review concludes by highlighting major research questions and technological limitations.

JOURNAL OF GENERAL PHYSIOLOGY (2022)

Article Multidisciplinary Sciences

Ultrasound activates mechanosensitive TRAAK K+ channels through the lipid membrane

Ben Sorum et al.

Summary: Ultrasound has been shown to modulate the electrical activity of excitable cells by activating mechanosensitive channels, which may have implications for targeted neuromodulation in the future. This discovery provides a new theoretical basis for the application of ultrasound in neuroscience.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

Article Biology

Piezo1 ion channels inherently function as independent mechanotransducers

Amanda H. Lewis et al.

Summary: Piezo1 is a mechanically activated ion channel involved in sensing forces in various cell types and tissues. Studies show that Piezo1 channels are randomly distributed across the cell surface and do not tend to cluster together, suggesting that they act independently and are not influenced by proximity to one another. This property may ensure that all parts of the cell surface react homogeneously to mechanical force.

ELIFE (2021)

Article Neurosciences

Physical basis for distinct basal and mechanically gated activity of the human K+ channel TRAAK

Robert A. Rietmeijer et al.

Summary: TRAAK is a mechanosensitive two-pore domain K+ (K2P) channel essential for mechanical and thermal allodynia in neurons, with distinct conductance, kinetics, and structural differences between basal and mechanically gated openings. Understanding these dual modes of activity could lead to the development of state-selective pharmacology for potential disease treatment.

NEURON (2021)

Article Endocrinology & Metabolism

Piezo1 Inactivation in Chondrocytes Impairs Trabecular Bone Formation

Gretl Hendrickx et al.

Summary: The skeleton is a dynamic tissue that continuously adapts to mechanical stimuli. Piezo1 plays a critical role in bone formation, specifically in endochondral ossification. Deletion of Piezo1 may lead to osteoporosis and spontaneous fractures.

JOURNAL OF BONE AND MINERAL RESEARCH (2021)

Article Chemistry, Physical

Cortical cell stiffness is independent of substrate mechanics

Johannes Rheinlaender et al.

NATURE MATERIALS (2020)

Article Multidisciplinary Sciences

A dietary fatty acid counteracts neuronal mechanical sensitization

Luis O. Romero et al.

NATURE COMMUNICATIONS (2020)

Article Multidisciplinary Sciences

Force-induced conformational changes in PIEZO1

Yi-Chih Lin et al.

NATURE (2019)

Article Multidisciplinary Sciences

Piezo2 integrates mechanical and thermal cues in vertebrate mechanoreceptors

Wang Zheng et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

Article Biology

Myosin-II mediated traction forces evoke localized Piezo1-dependent Ca2+ flickers

Kyle L. Ellefsen et al.

COMMUNICATIONS BIOLOGY (2019)

Article Acoustics

ACTIVATION OF PIEZO1 BUT NOT NA(v)1.2 CHANNELS BY ULTRASOUND AT 43 MHZ

Martin Loynaz Prieto et al.

ULTRASOUND IN MEDICINE AND BIOLOGY (2018)

Article Neurosciences

Cell Mechanotransduction With Piconewton Forces Applied by Optical Tweezers

Fabio Falleroni et al.

FRONTIERS IN CELLULAR NEUROSCIENCE (2018)

Article Biochemistry & Molecular Biology

Cell Membranes Resist Flow

Zheng Shi et al.

Article Multidisciplinary Sciences

PIEZOs mediate neuronal sensing of blood pressure and the baroreceptor reflex

Wei-Zheng Zeng et al.

SCIENCE (2018)

Review Anatomy & Morphology

A beginner's guide to atomic force microscopy probing for cell mechanics

Nuria Gavara

MICROSCOPY RESEARCH AND TECHNIQUE (2017)

Article Biochemistry & Molecular Biology

Bilayer-Mediated Structural Transitions Control Mechanosensitivity of the TREK-2 K2P Channel

Prafulla Aryal et al.

STRUCTURE (2017)

Article Biochemistry & Molecular Biology

A Non-canonical Voltage-Sensing Mechanism Controls Gating in K2P K+ Channels

Marcus Schewe et al.

Article Biochemistry & Molecular Biology

Regulation of Piezo2 Mechanotransduction by Static Plasma Membrane Tension in Primary Afferent Neurons

Zhanfeng Jia et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2016)

Article Engineering, Biomedical

Cell elasticity with altered cytoskeletal architectures across multiple cell types

Martha E. Grady et al.

JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS (2016)

Article Multidisciplinary Sciences

Mixing and matching TREK/TRAAK subunits generate heterodimeric K2P channels with unique properties

Sandy Blin et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)

Article Multidisciplinary Sciences

Removal of the mechanoprotective influence of the cytoskeleton reveals PIEZO1 is gated by bilayer tension

Charles D. Cox et al.

NATURE COMMUNICATIONS (2016)

Article Multidisciplinary Sciences

Localized force application reveals mechanically sensitive domains of Piezo1

Jason Wu et al.

NATURE COMMUNICATIONS (2016)

Article Cell Biology

Piezo1 Channels Are Inherently Mechanosensitive

Ruhma Syeda et al.

CELL REPORTS (2016)

Article Multidisciplinary Sciences

How ion channels sense mechanical force: insights from mechanosensitive K2P channels TRAAK, TREK1, and TREK2

Stephen G. Brohawn

ANNALS REPORTS, VOL 1352 (2015)

Article Biochemistry & Molecular Biology

Ankyrin Repeats Convey Force to Gate the NOMPC Mechanotransduction Channel

Wei Zhang et al.

Article Neurosciences

Piezo2 is the principal mechanotransduction channel for proprioception

Seung-Hyun Woo et al.

NATURE NEUROSCIENCE (2015)

Article Multidisciplinary Sciences

Piezo1 ion channel pore properties are dictated by C-terminal region

Bertrand Coste et al.

NATURE COMMUNICATIONS (2015)

Article Neurosciences

ATOMIC FORCE MICROSCOPY AS AN ADVANCED TOOL IN NEUROSCIENCE

Maja Jazvinscak Jembrek et al.

TRANSLATIONAL NEUROSCIENCE (2015)

Article Multidisciplinary Sciences

Piezo2 is the major transducer of mechanical forces for touch sensation in mice

Sanjeev S. Ranade et al.

NATURE (2014)

Article Multidisciplinary Sciences

Epidermal Merkel cells are mechanosensory cells that tune mammalian touch receptors

Srdjan Maksimovic et al.

NATURE (2014)

Article Multidisciplinary Sciences

Physical mechanism for gating and mechano sensitivity of the human TRAAK K+ channel

Stephen G. Brohawn et al.

NATURE (2014)

Article Multidisciplinary Sciences

Piezo2 is required for Merkel-cell mechanotransduction

Seung-Hyun Woo et al.

NATURE (2014)

Article Multidisciplinary Sciences

Stretch-activated ion channel Piezo1 directs lineage choice in human neural stem cells

Medha M. Pathak et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

Article Multidisciplinary Sciences

Synergy between Piezo1 and Piezo2 channels confers high-strain mechanosensitivity to articular cartilage

Whasil Lee et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

Article Multidisciplinary Sciences

Mechanosensitivity is mediated directly by the lipid membrane in TRAAK and TREK1 K+ channels

Stephen G. Brohawn et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

Article Multidisciplinary Sciences

Piezo1, a mechanically activated ion channel, is required for vascular development in mice

Sanjeev S. Ranade et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

Article Multidisciplinary Sciences

Tuning Piezo ion channels to detect molecular-scale movements relevant for fine touch

Kate Poole et al.

NATURE COMMUNICATIONS (2014)

Article Biochemistry & Molecular Biology

The Purified Mechanosensitive Channel TREK-1 Is Directly Sensitive to Membrane Tension

Catherine Berrier et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2013)

Article Biochemistry & Molecular Biology

Gating the mechanical channel Piezo1 A comparison between whole-cell and patch recording

Philip A. Gottlieb et al.

CHANNELS (2012)

Article Multidisciplinary Sciences

Piezo proteins are pore-forming subunits of mechanically activated channels

Bertrand Coste et al.

NATURE (2012)

Article Biophysics

Cell Shape and Substrate Rigidity Both Regulate Cell Stiffness

Shang-You Tee et al.

BIOPHYSICAL JOURNAL (2011)

Article Biochemistry & Molecular Biology

Cells Respond to Mechanical Stress by Rapid Disassembly of Caveolae

Bidisha Sinha et al.

Article Biochemical Research Methods

Recording of mechanosensitive currents using piezoelectrically driven mechanostimulator

Jizhe Hao et al.

NATURE PROTOCOLS (2011)

Review Biochemistry & Molecular Biology

Biophysical, pharmacological, functional characteristics of cloned and native mammalian two-pore domain K+ channels

David P. Lotshaw

CELL BIOCHEMISTRY AND BIOPHYSICS (2007)

Article Physiology

High-speed pressure clamp

SR Besch et al.

PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY (2002)

Article Biophysics

Direct measurement of specific membrane capacitance in neurons

LJ Gentet et al.

BIOPHYSICAL JOURNAL (2000)