Journal
JOURNAL OF VIROLOGY
Volume 90, Issue 9, Pages 4843-4848Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.03223-15
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Funding
- Bundesministerium fur Bildung und Forschung (BMBF) [PTJ-BIO2, BIO-428-066]
- CHS Foundation
- Helmholtz-Chinese Academy of Sciences [HCJRG-202]
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Histo-blood group antigens (HBGAs) are important binding factors for norovirus infections. We show that two human milk oligosaccharides, 2'-fucosyllactose (2'FL) and 3-fucosyllactose (3FL), could block norovirus from binding to surrogate HBGA samples. We found that 2'FL and 3FL bound at the equivalent HBGA pockets on the norovirus capsid using X-ray crystallography. Our data revealed that 2'FL and 3FL structurally mimic HBGAs. These results suggest that 2'FL and 3FL might act as naturally occurring decoys in humans.
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