Journal
CHANNELS
Volume 9, Issue 1, Pages 5-13Publisher
TAYLOR & FRANCIS INC
DOI: 10.4161/19336950.2014.995001
Keywords
inflammation pain; neuropathic pain; protease-activated receptor 4
Categories
Funding
- National Natural Science Foundation Project of China [81273718, 81302961]
Ask authors/readers for more resources
Pain is an unpleasant sensory and emotional experience that is commonly associated with actual or potential tissue damage. Despite decades of pain research, many patients continue to suffer from chronic pain that is refractory to current treatments. Accumulating evidence has indicated an important role of protease-activated receptor 4 (PAR4) in the pathogenesis of inflammation and neuropathic pain. Here we reviewed PAR4 expression and activation via intracellular signaling pathways and the role of PAR4 signaling pathways in the development and maintenance of pain. Understanding PAR4 and its corresponding signaling pathways will provide insight to further explore the molecular basis of pain, which will also help to identify new targets for pharmacological intervention for pain relief.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available