4.0 Article

Estimating sequence diversity of prion protein gene (PRNP) in Portuguese populations of two cervid species: red deer and fallow deer

Related references

Note: Only part of the references are listed.
Review Biochemistry & Molecular Biology

Cervid Prion Protein Polymorphisms: Role in Chronic Wasting Disease Pathogenesis

Maria Immaculata Arifin et al.

Summary: Chronic wasting disease (CWD) is a prion disease found in both free-ranging and farmed cervids, with susceptibility governed by various factors, including PrP polymorphisms. While most polymorphisms reduce susceptibility to CWD, there have been no reports of cervid PrP alleles providing absolute resistance to CWD. Studies have focused on understanding the role of animal genetics in predicting, containing, or preventing transmission of CWD in endemic areas.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Review Biochemistry & Molecular Biology

Neuropathology of Animal Prion Diseases

Leonor Orge et al.

Summary: Transmissible Spongiform Encephalopathies (TSEs) are a fatal group of infectious, inherited, and spontaneous neurodegenerative diseases that affect both humans and animals. These diseases are caused by the conversion of cellular prion protein into a misfolded pathological isoform, leading to neuropathological lesions like spongiform changes, neuronal loss, and accumulation of PrPSc. The different PrPSc conformers may result in various prion strains, highlighting the importance of investigating lesion profiles in naturally affected animals. Although the mechanisms of neurodegeneration and brain inflammation in these diseases are not well understood, research in this area is crucial.

BIOMOLECULES (2021)

Review Veterinary Sciences

Review on PRNP genetics and susceptibility to chronic wasting disease of Cervidae

Katayoun Moazami-Goudarzi et al.

Summary: Chronic wasting disease (CWD) is highly infectious and affects captive, free-ranging, and wild cervid species. Polymorphisms in the prion protein gene (PRNP) play a significant role in susceptibility and propagation rates, with genetic differences potentially affecting disease progression. CWD poses a zoonotic risk due to its ability to cross species barriers.

VETERINARY RESEARCH (2021)

Article Biodiversity Conservation

Geographic Distribution of Chronic Wasting Disease Resistant Alleles in Nebraska, with Comments on the Evolution of Resistance

Hernan Vazquez-Miranda et al.

JOURNAL OF FISH AND WILDLIFE MANAGEMENT (2020)

Article Biochemistry & Molecular Biology

Chronic wasting disease (CWD) prion strains evolve via adaptive diversification of conformers in hosts expressing prion protein polymorphisms

Camilo Duque Velasquez et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2020)

Article Multidisciplinary Sciences

Shedding and stability of CWD prion seeding activity in cervid feces

Joanne M. Tennant et al.

PLOS ONE (2020)

Article Immunology

Prion Disease in Dromedary Camels, Algeria

Baaissa Babelhadj et al.

EMERGING INFECTIOUS DISEASES (2018)

Article Veterinary Sciences

Low sequence diversity of the prion protein gene (PRNP) in wild deer and goat species from Spain

Jose Luis Pitarch et al.

VETERINARY RESEARCH (2018)

Article Biotechnology & Applied Microbiology

Detection of chronic wasting disease prion seeding activity in deer and elk feces by real-time quaking-induced conversion

Davin M. Henderson et al.

JOURNAL OF GENERAL VIROLOGY (2017)

Article Veterinary Sciences

First case of chronic wasting disease in Europe in a Norwegian free-ranging reindeer

Sylvie L. Benestad et al.

VETERINARY RESEARCH (2016)

Article Agriculture, Dairy & Animal Science

Chronic Wasting Disease of Cervids: Current Knowledge and Future Perspectives

Nicholas J. Haley et al.

ANNUAL REVIEW OF ANIMAL BIOSCIENCES, VOL 3 (2015)

Article Biochemical Research Methods

Unipro UGENE: a unified bioinformatics toolkit

Konstantin Okonechnikov et al.

BIOINFORMATICS (2012)

Article Multidisciplinary Sciences

Experimental Oral Transmission of Chronic Wasting Disease to Reindeer (Rangifer tarandus tarandus)

Gordon B. Mitchell et al.

PLOS ONE (2012)

Article Biochemical Research Methods

Jalview Version 2-a multiple sequence alignment editor and analysis workbench

Andrew M. Waterhouse et al.

BIOINFORMATICS (2009)

Review Veterinary Sciences

Bovine spongiform encephalopathy

Jane L. Harman et al.

JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION (2009)

Article Veterinary Sciences

Genetic variability of the prion protein gene (PRNP) in wild ruminants from Italy and Scotland

Simone Peletto et al.

JOURNAL OF VETERINARY SCIENCE (2009)

Article Biotechnology & Applied Microbiology

Prion protein polymorphisms in white-tailed deer influence susceptibility to chronic wasting disease

Chad Johnson et al.

JOURNAL OF GENERAL VIROLOGY (2006)