Biocompatibility evaluation of nano-hydroxyapatite modified hydroxypropyl methylcellulose/polyvinylpyrrolidone blends

Blending of polymers can be utilized to improve the properties of the new hybrid system without sacrificing the individual characteristics of the components. A combination of biocompatible cellulose-based polymer, hydroxypropyl methylcellulose (HPMC) and synthetic biocompatible polymer polyvinyl pyrrolidone (PVP) has been designed to modify the mechanical and thermal properties via blending strategy. This work investigates the modification of HPMC and PVP blends through plasticizing with polyethylene glycol (PEG 6000, a non-toxic plasticizer to improve the flexibility of the matrix. The optimized blend system has been embedding with nHA as a biocompatible multifunctional filler to reinforce the polymer matrix for improving the efficacy in biomedical applications. The characterization has been extended through the evaluation of FTIR, XRD, TGA, DSC, SEM and UV-Visible spectroscopy. The reinforced blend has been found to match the requirements for fabricating wound healing patches in the biosector.

Automated summary

Blending of polymers can improve the properties of the hybrid system without sacrificing component characteristics. A combination of biocompatible cellulose-based polymer HPMC and synthetic biocompatible polymer PVP has been designed for modifying mechanical and thermal properties. Plasticizing with non-toxic plasticizer PEG 6000 has been used to improve flexibility, and the addition of biocompatible filler nHA has reinforced the polymer matrix. The optimized blend meets the requirements for fabricating wound healing patches in the biosector.