Antibacterial Activity of Novel 1-Cyclopropyl-6,7-Difluoro-8-Methoxy-4-Oxo-1,4-Dihydroquinoline-3-Carbohydrazide Derivatives

Article Chemistry, Multidisciplinary

Click chemistry inspired syntheses of new amide linked 1,2,3-triazoles from naphthols: biological evaluation and in silico computational study

Satish V. V. Akolkar et al.

Summary: A small library of 1,2,3-triazole derivatives derived from naphthols has been efficiently synthesized through the click chemistry approach for the search of new active molecules. The synthesized compounds were evaluated for their antifungal, antioxidant, and antitubercular activities. Furthermore, a molecular docking study was conducted to understand the binding affinity and interactions between the enzyme and the synthesized derivatives, revealing a significant correlation between the binding score and biological activity of these compounds. The results suggest that the 1,2,3-triazole derivatives may serve as potential candidates for the development of novel therapeutic agents.

RESEARCH ON CHEMICAL INTERMEDIATES (2023)

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Article Chemistry, Organic

[Et3NH][HSO4]-Catalyzed One-Pot Solvent Free Syntheses of Functionalized [1,6]-Naphthyridines and Biological Evaluation

Mubarak H. Shaikh et al.

Summary: A convenient method for synthesizing highly functionalized [1,6]-naphthyridines under solvent-free condition was developed, with evaluation of their in vitro activities. Additionally, molecular docking studies revealed the binding patterns of these compounds with the target protein, and ADME parameters indicated their potential as oral drug candidates.

POLYCYCLIC AROMATIC COMPOUNDS (2022)

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Article Chemistry, Physical

Synthesizes, characterization, molecular docking and in vitro bioactivity study of new compounds containing triple beta lactam rings

Marwan Mohammed Farhan et al.

Summary: This study synthesized two compounds with triple B-lactam rings and demonstrated their effective antibacterial activity in vitro. Molecular docking studies showed their strong binding affinity to the target protein. These novel compounds show promise for future in vivo studies.

JOURNAL OF MOLECULAR STRUCTURE (2022)

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Article Chemistry, Multidisciplinary

Synthesis, Molecular Modeling Study, and Quantum-Chemical-Based Investigations of Isoindoline-1,3-diones as Antimycobacterial Agents

Iqrar Ahmad et al.

Summary: Structurally modified isoindoline-1,3-dione derivatives were synthesized from the condensation of phthalic anhydride with selected amino-containing compounds. These compounds exhibited antimycobacterial activity, with compound 27 being the most potent. Computational studies were conducted to understand the reactivity and stability of these compounds as InhA inhibitors.

ACS OMEGA (2022)

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Article Chemistry, Organic