Synthesis and Antimicrobial Activity of New Carbohydrazide Bearing Quinoline Scaffolds in Silico ADMET and Molecular Docking Studies

In search of a more potent and new series of fluorine-containing quinoline, hybrid Schiff bases (6a-o) analogues were synthesized by a facile and efficient conventional method. They were developed via condensation of quinoline-4-carbohydrazide intermediate and aromatic aldehydes in presence of ethanol. All compounds viz., 6a-o were efficiently synthesized in good yields in ranges of 76-84%, respectively. All synthesized compounds were well characterized by using various spectroscopic techniques such as FT-IR, H-1 NMR, C-13 NMR, Mass spectroscopy. Moreover, all newly synthesized hybrid Schiff bases (6a-o) have been screened for their antifungal and antibacterial activity. Among these compounds (6a-d) shows good antibacterial activity, while compound 6b was found to be effective against a fungal pathogen Aspergillus niger and compound 6a was found to inhibit the visible growth of Staphylococcus aureus ATCC 6538 at low concentration with MIC 340 mu g/. [GRAPHICS] .

Automated summary

A series of fluorine-containing quinoline analogues, known as hybrid Schiff bases (6a-o), were successfully synthesized through a facile and efficient conventional method. These compounds were developed via the condensation of a quinoline-4-carbohydrazide intermediate and aromatic aldehydes using ethanol as a solvent. All synthesized compounds (6a-o) exhibited good yields ranging from 76% to 84%. The synthesized compounds were comprehensively characterized using various spectroscopic techniques, including FT-IR, H-1 NMR, C-13 NMR, and Mass spectroscopy. Additionally, the antifungal and antibacterial activity of the newly synthesized hybrid Schiff bases (6a-o) were evaluated. Compounds 6a-d showed promising antibacterial activity, while compound 6b exhibited effectiveness against the fungal pathogen Aspergillus niger. Compound 6a was found to inhibit the visible growth of Staphylococcus aureus ATCC 6538 at a low concentration with a minimum inhibitory concentration of 340 μg/.