4.6 Article

Lost in HELLS: Disentangling the mystery of SALNR existence in senescence cellular models

Related references

Note: Only part of the references are listed.
Review Cell Biology

Mechanisms of lncRNA biogenesis as revealed by nascent transcriptomics

Takayuki Nojima et al.

Summary: Mammalian genomes express protein-coding and non-coding RNA genes. Recent studies have revealed differences in transcription initiation and termination between non-coding RNA genes and protein-coding genes, which are relevant to genomic stress and DNA damage.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2022)

Article Oncology

HELLS Is Negatively Regulated by Wild-Type P53 in Liver Cancer by a Mechanism Involving P21 and FOXM1

Stefanie Schuller et al.

Summary: The tumor suppressor protein P53 plays a crucial role in preventing liver cancer development, and it negatively regulates the expression of HELLS, an important regulator in liver cancer. The regulatory mechanism involves the induction of P21 and repression of FOXM1, resulting in the downregulation of HELLS expression. This study provides new insights into the epigenetic regulation of liver cancer and the tumor suppressive function of P53.

CANCERS (2022)

Review Oncology

Lymphoid-specific helicase in epigenetics, DNA repair and cancer

Xiangyu Chen et al.

Summary: LSH, a member of the SNF2 helicase family, is involved in various aspects of epigenetic regulation and plays a crucial role in DNA-damage repair and tumorigenesis, making it a potential biomarker for cancer. Research on the role of LSH in cancers and key questions for future studies are summarized.

BRITISH JOURNAL OF CANCER (2022)

Article Biology

Telomere damage promotes vascular smooth muscle cell senescence and immune cell recruitment after vessel injury

Anna K. Uryga et al.

Summary: Accumulation of vascular smooth muscle cells (VSMCs) is a hallmark of multiple vascular pathologies. The study suggests that persistent telomere damage in VSMCs inducing cell senescence has a major role in driving persistent inflammation in vascular disease. The findings indicate that telomere injury and DNA damage can be primary causes of premature senescence and persistent inflammation in VSMCs.

COMMUNICATIONS BIOLOGY (2021)

Article Cell Biology

ATF3 drives senescence by reconstructing accessible chromatin profiles

Chao Zhang et al.

Summary: The study revealed a massive redistribution of chromatin accessibility in human umbilical vein endothelial cell (HUVEC) senescence, with AP-1 transcription factor family identified as crucial in driving this chromatin accessibility reconstruction. The remodeling of chromatin accessibility by AP-1 contributes to the senescence program, particularly through changes in intergenic chromatin regions. Additionally, ATF3 was found to be critical in promoting cellular senescence by reconstructing chromatin accessibility.

AGING CELL (2021)

Article Cell Biology

Senolytic vaccination improves normal and pathological age-related phenotypes and increases lifespan in progeroid mice

Masayoshi Suda et al.

Summary: The study identified GPNMB as a target for senolytic therapy, and immunization against GPNMB improved normal and pathological phenotypes associated with aging, extending the lifespan of aging mice.

NATURE AGING (2021)

Review Neurosciences

Cellular Senescence in Neurodegenerative Diseases

Carmen Martinez-Cue et al.

FRONTIERS IN CELLULAR NEUROSCIENCE (2020)

Review Genetics & Heredity

Long-read human genome sequencing and its applications

Glennis A. Logsdon et al.

NATURE REVIEWS GENETICS (2020)

Review Biochemistry & Molecular Biology

LncRNAs Regulatory Networks in Cellular Senescence

Pavan Kumar Puvvula

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Article Biochemistry & Molecular Biology

LNCipedia 5: towards a reference set of human long non-coding RNAs

Pieter-Jan Volders et al.

NUCLEIC ACIDS RESEARCH (2019)

Review Cell Biology

Hallmarks of Cellular Senescence

Alejandra Hernandez-Segura et al.

TRENDS IN CELL BIOLOGY (2018)

Review Genetics & Heredity

Epigenetic regulation in cell senescence

Li-Qin Cheng et al.

JOURNAL OF MOLECULAR MEDICINE-JMM (2017)

Article Biochemical Research Methods

A fuzzy method for RNA-Seq differential expression analysis in presence of multireads

Arianna Consiglio et al.

BMC BIOINFORMATICS (2016)

Article Biotechnology & Applied Microbiology

Similarities in Gene Expression Profiles during In Vitro Aging of Primary Human Embryonic Lung and Foreskin Fibroblasts

Shiva Marthandan et al.

BIOMED RESEARCH INTERNATIONAL (2015)

Article Biochemical Research Methods

STAR: ultrafast universal RNA-seq aligner

Alexander Dobin et al.

BIOINFORMATICS (2013)

Review Biochemistry & Molecular Biology

The Hallmarks of Aging

Carlos Lopez-Otin et al.

Review Biochemistry & Molecular Biology

Ageing as a Risk Factor for Disease

Teresa Niccoli et al.

CURRENT BIOLOGY (2012)