Diagnosis and Outcomes of 225 Consecutive Cases of Complex Regional Pain Syndrome of the Hand

Background: The lack of specific tests and potential diagnostic inaccuracy may be behind the stunning figures of complex regional pain syndrome (CRPS) cases. The author tested the hypothesis that patients diagnosed with CRPS at referral could be assigned to recognized conditions and treated accordingly.Methods: From January of 2018 to April of 2021, 225 consecutive patients attended the author's office having been diagnosed with and treated for CRPS for an average of 16 +/- 26 months. There were 180 women and 45 men; no patient was excluded.Results: All patients could be allocated in named conditions: 79 had a wrong diagnosis; seven had a true causalgia; 16 were dystonic-psychogenic hands; 20 presented a flare reaction; and 90 had an irritative carpal tunnel syndrome. The remaining 13 patients had a miscellany of symptoms within a substandard management setting. Surgery was offered to 175 with a correctable cause; 50 (20 of whom had a tangible cause responsible for their pain) declined, and their outcome is unknown. The remaining 125 were operated on and tracked for an average of 20 +/- 9 months. In the operated group, pain dropped 7.5 +/- 2.2 points (P < 0.0001) on a numerical rating scale of 0 to 10. Disabilities of the Arm, Shoulder, and Hand questionnaire scores fell from 80 to 16 (P < 0.0001). Patients who were operated on rated their satisfaction on a scale of 0 to 10 as 8.9 +/- 1.9.Conclusions: Unlike with CRPS, all patients in this series had a true, diagnosable condition explaining their clinical picture. Most patients who agreed to be operated on had a favorable outcome. (Plast. Reconstr. Surg. 152: 807, 2023.)CLINICAL QUESTION/LEVEL OF EVIDENCE: Therapeutic, IV.

Automated summary

The study showed that all patients diagnosed with CRPS actually had specific underlying conditions explaining their clinical symptoms, and most patients who underwent surgery had a favorable outcome.