Journal
JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS
Volume 40, Issue 3, Pages 293-303Publisher
WILEY
DOI: 10.1111/jvp.12356
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Funding
- Youth Program for Scholar and Innovative Research Teams in Tarim University [TDZKQN201603]
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To effectively control bovine mastitis, tilmicosin (TIL)- and florfenicol (FF)-loaded solid lipid nanoparticles (SLN) with hydrogenated castor oil (HCO) were prepared by a hot homogenization and ultrasonication method. In vitro antibacterial activity, properties, and pharmacokinetics of the TIL-FF-SLN were studied. The results demonstrated that TIL and FF had a synergistic or additive antibacterial activity against Streptococcus dysgalactiae, Streptococcus uberis, and Streptococcus agalactiae. The size, polydispersity index, and zeta potential of nanoparticles were 289.1 +/- 13.7nm, 0.31 +/- 0.05, and -26.7 +/- 1.3 mV, respectively. The encapsulation efficiencies for TIL and FF were 62.3 +/- 5.9% and 85.1 +/- 5.2%, and the loading capacities for TIL and FF were 8.2 +/- 0.6% and 3.3 +/- 0.2%, respectively. The TIL-FF-SLN showed no irritation in the injection site and sustained release invitro. After medication, TIL and FF could maintain about 0.1g/mL for 122 and 6h. Compared to the control solution, the SLN increased the area under the concentration-time curve (AUC(0-t)), elimination half-life (T-1/2ke), and mean residence time (MRT) of TIL by 33.09-, 23.29-, and 37.53-fold, and 1.69-, 5.00-, and 3.83-fold for FF, respectively. These results of this exploratory study suggest that the HCO-SLN could be a useful system for the delivery of TIL and FF for bovine mastitis therapy.
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