Journal
JOURNAL OF VETERINARY MEDICAL SCIENCE
Volume 78, Issue 11, Pages 1643-1647Publisher
JAPAN SOC VET SCI
DOI: 10.1292/jvms.16-0347
Keywords
inflammation; PGD(2); tumor; vascular permeability
Categories
Funding
- Japan Society for the Promotion of Science
- Foundation for Dietary Scientific Research
- Naito Foundation
- Kurozumi Medical Foundation
- Cardiovascular Research Fund
- Suzuken Memorial Foundation
- Nippon Ham Foundation
- Japan Foundation for Pediatric Research
- Sapporo Bioscience Foundation
- Grants-in-Aid for Scientific Research [15J10812] Funding Source: KAKEN
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Nonsteroidal anti-inflammatory drugs (NSAIDs) including aspirin are one of the most frequently used classes of drug worldwide and inhibit prostaglandin (PG) production by inhibiting cyclooxygenase activity. Although NSAIDs are broadly used against inflammatory diseases, they have side effects including alimentary canal disorders, kidney damage, infection and cardiovascular disorders. Thus, it is necessary to elucidate the pathophysiological role of each PG in various diseases to develop better therapies with fewer and milder side effects. PGD(2) is a PG that was identified in 1973 by Hamberg and is produced by the activities of cyclooxygenase and either hematopoietic or lipocalin-type PGD synthase. PGD(2) exerts its physiological effects by stimulating two distinct G protein-coupled receptors, namely D prostanoid receptor (DP) and chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2). The physiological role of PGD(2) remains controversial. Some studies have reported that PGD(2) has bronchoconstrictory and pro-inflammatory effects inducing immune cell accumulation. In contrast, other groups have reported that PGD(2) has anti-inflammatory effects by inhibiting the recruitment of dendritic cells and neutrophils. We have investigated the pathophysiological role of PGD(2) using various disease models and reported on its anti-inflammatory actions. Here, we review the anti-inflammatory roles of PGD(2) and the underlying mechanisms.
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