A tri-herb formulation protects against ethanol-induced mouse liver injury and downregulates mitogen-activated protein kinase phosphatase 1

Review Pharmacology & Pharmacy

Old wine in new bottles: Kaempferol is a promising agent for treating the trilogy of liver diseases

Xiaolin Xiao et al.

Summary: Kaempferol (KP) has shown good pharmacological effects on a series of complex liver diseases by regulating precise signaling targets and is expected to become an emerging therapeutic opportunity to treat liver diseases in the future.

PHARMACOLOGICAL RESEARCH (2022)

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Article Food Science & Technology

Ganoderic acids-rich ethanol extract from Ganoderma lucidum protects against alcoholic liver injury and modulates intestinal microbiota in mice with excessive alcohol intake

Wei-Ling Guo et al.

Summary: Ganoderma lucidum ethanol extract (GLE) has a protective effect against alcoholic liver injury by reducing abnormal lipid levels, attenuating hepatic lipid accumulation and pathological changes, ameliorating oxidative stress, regulating gut microbiota, and modulating liver metabolites and gene expression related to fatty acid metabolism, ethanol catabolism, and inflammatory response.

CURRENT RESEARCH IN FOOD SCIENCE (2022)

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Article Medicine, Research & Experimental

Puerariae Lobatae radix flavonoids and puerarin alleviate alcoholic liver injury in zebrafish by regulating alcohol and lipid metabolism

Yu-Shi Liu et al.

Summary: The study demonstrated that PLR flavonoids and puerarin can alleviate alcohol-induced hepatic steatosis in zebrafish larvae by regulating alcohol and lipid metabolism, which is closely related to the AMPKα-ACC signaling pathway.

BIOMEDICINE & PHARMACOTHERAPY (2021)

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Article Plant Sciences

Luteolin ameliorates LPS-induced acute liver injury by inhibiting TXNIP-NLRP3 inflammasome in mice

Xiaohui Wang et al.

Summary: Luteolin effectively protects against acute liver injury induced by LPS through inhibiting the TXNIP-NLRP3 axis, thereby reducing NLRP3 inflammasome activation and liver inflammation, as well as alleviating oxidative stress and hepatocyte injury.

PHYTOMEDICINE (2021)

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Review Biochemistry & Molecular Biology

Liver Disease: Induction, Progression, Immunological Mechanisms, and Therapeutic Interventions

Sarah Y. Neshat et al.

Summary: The liver has impressive regenerative potential but certain diseases can lead to liver fibrosis and eventually cirrhosis. This review discusses the complex immunological activities in liver diseases and the potential of mesenchymal stem cells in treatment. Preclinical studies show promising results in inhibiting host immunity, with ongoing clinical trials exploring cellular and non-cellular therapies for liver cirrhosis detection and treatment.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Meeting Abstract Biochemistry & Molecular Biology