4.7 Review

Hypericin: A natural anthraquinone as promising therapeutic agent

Journal

PHYTOMEDICINE
Volume 111, Issue -, Pages -

Publisher

ELSEVIER GMBH
DOI: 10.1016/j.phymed.2023.154654

Keywords

Hypericin; Bioactivities; Photodynamic therapy (PDT); Drug delivery system (DDS)

Ask authors/readers for more resources

This review provides a comprehensive summary and analysis of the extensive pharmacological applications of hypericin. By reviewing the literature, it presents conclusions on the natural and artificial sources of hypericin, strategies to improve its bioactivity, pharmacological activities, and drug combinations, and explores the future therapeutic potential of this active compound.
Background: Hypericin is a prominent secondary metabolite mainly existing in genus Hypericum. It has become a research focus for a quiet long time owing to its extensively pharmacological activities especially the anti-cancer, anti-bacterial, anti-viral and neuroprotective effects. This review concentrated on summarizing and analyzing the existing studies of hypericin in a comprehensive perspective. Methods: The literature with desired information about hypericin published after 2010 was gained from electronic databases including PubMed, SciFinder, Science Direct, Web of Science, China National Knowledge Infrastructure databases and Wan Fang DATA. Results: According to extensive preclinical and clinical studies conducted on the hypericin, an organized and comprehensive summary of the natural and artificial sources, strategies for improving the bioactivities, pharmacological activities, drug combination of hypericin was presented to explore the future therapeutic potential of this active compound. Conclusions: Overall, this review offered a theoretical guidance for the follow-up research of hypericin. However, the pharmacological mechanisms, pharmacokinetics and structure activity relationship of hypericin should be further studied in future research.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.7
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

No Data Available
No Data Available