Journal
PHYTOCHEMISTRY
Volume 209, Issue -, Pages -Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.phytochem.2023.113622
Keywords
Garcinia cowa; Clusiaceae; Benzoylphloroglucinol; Garcowacinol; Cytotoxic
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Ten undescribed polyprenylated benzoylphloroglucinol derivatives named garcowacinols A-J (1-10) and four known analogues (11-14) were isolated from the twigs of Garcinia cowa. Their structures were determined by spectroscopic data analysis, and their absolute configurations were established based on NOESY and ECD data. The isolated compounds were evaluated for their cytotoxicity against human cancer cells, and Garcowacinol C showed significant activity against all five cancer cell lines.
Ten undescribed polyprenylated benzoylphloroglucinol derivatives named garcowacinols A-J (1-10) and four known analogues (11-14) were isolated from the twigs of Garcinia cowa. Their structures were determined by spectroscopic data analysis (1D and 2D NMR and HRESIMS), and their absolute configurations were established based on NOESY and ECD data. All isolated compounds were evaluated for their cytotoxicity against five types of human cancer cells (KB, HeLa S3, MCF-7, Hep G2, and HT-29) as well as Vero cells by MTT colorimetric assay. Garcowacinol C was significantly active against all the five cancer cells with IC50 values in the range of 0.61-9.50 mu M. Selective proliferative inhibitions were observed on garcowacinol F and 7-epiclusianone against KB cells, and guttiferone Q toward MCF-7 cells with IC50 values less than 10 mu M.
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