Journal
PHYTOCHEMISTRY
Volume 210, Issue -, Pages -Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.phytochem.2023.113673
Keywords
Salvia miltiorrhiza; Labiatae; Isolation and purification; Tanshinone; Structural elucidation; Antioxidant activities
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Six undescribed tanshinones were isolated from the rhizome of Salvia miltiorrhiza Bunge. They exhibited good antioxidant activities in cardiomyocytes and showed potential in protecting the cells.
Six undescribed tanshinones, (+)-2-Cl-tanshindiol C (1), (- )-2-Cl-tanshindiol C (2), (+)-tanshinoic acid D (3), (-)-tanshinoic acid D (4), (-)-tanshinoic acid E (5), and (+)-tanshinoic acid E (6), were isolated from the rhizome of Salvia miltiorrhiza Bunge. Their structures were elucidated based on the spectroscopic data (UV, IR, HR-ESI-MS, and NMR). The bioactive assays of all these compounds for the antioxidant activities in cardiomyocytes upon hypoxia stimulation were evaluated. The results suggested that compounds 5 and 6 exhibited good antioxidant activities in cardiomyocytes and the cell survival rates were 46.3% and 57.9% (10-5 mol/L), respectively.
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