Stability of Branched Tubular Membrane Structures

We study the energetics and stability of branched tubular membrane structures by computer simulations of a triangulated network model. We find that triple (Y) junctions can be created and stabilized by applying mechanical forces, if the angle between branches is 120 degrees. The same holds for tetrahedral junctions with tetraeder angles. If the wrong angles are enforced, the branches coalesce to a linear structure, a pure tube. After releasing the mechanical force, Y-branched structures remain metastable if one constrains the enclosed volume and the average curvature (the area difference) to a fixed value; tetrahedral junctions however split up into two Y junctions. Somewhat counterintuitively, the energy cost of adding a Y branch is negative in structures with fixed surface area and tube diameter, even if one accounts for the positive contribution of the additional branch end. For fixed average curvature, however, adding a branch also enforces a thinning of tubes, therefore the overall curvature energy cost is positive. Possible implications for the stability of branched networks structures in cells are discussed.

Automated summary

We study the energetics and stability of branched tubular membrane structures using computer simulations. We find that Y junctions and tetrahedral junctions can be created and stabilized by applying mechanical forces, with specific angles between branches. However, if the wrong angles are enforced, the branches coalesce into pure tubes. The energy cost of adding a Y branch is negative in structures with fixed surface area and tube diameter, but positive in structures with fixed average curvature.