Journal
JOURNAL OF VETERINARY DIAGNOSTIC INVESTIGATION
Volume 28, Issue 5, Pages 579-583Publisher
SAGE PUBLICATIONS INC
DOI: 10.1177/1040638716659903
Keywords
Adenovirus; esophagitis; reptiles; stomatitis; Testudo graeca; tortoises
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Funding
- Servei de Diagnostic de Patologia Veterinaria (Universitat Autonoma Barcelona)
- Hungarian Scientific Research Fund [OTKA K100163]
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A 2-year-old female, spur-thighed tortoise (Testudo graeca) was presented with poor body condition (1/5) and weakness. Fecal analysis revealed large numbers of oxyurid-like eggs, and radiographs were compatible with gastrointestinal obstruction. Despite supportive medical treatment, the animal died. At gross examination, an intestinal obstruction was confirmed. Histopathology revealed severe hyperplastic esophagitis and stomatitis with marked epithelial cytomegaly and enormous basophilic intranuclear inclusion bodies. Electron microscopy examination revealed a large number of 60-80 nm, nonenveloped, icosahedral virions arranged in crystalline arrays within nuclear inclusions of esophageal epithelial cells, morphologically compatible with adenovirus-like particles. PCR for virus identification was performed with DNA extracted from formalin-fixed, paraffin-embedded tissues. A nested, consensus pan-adenovirus PCR and sequencing analysis showed a novel adenovirus. According to phylogenetic calculations, it clustered to genus Atadenovirus in contrast with all other chelonian adenoviruses described to date. The present report details the pathologic findings associated with an adenovirus infection restricted to the upper digestive tract.
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