Journal
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
Volume 42, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.pdpdt.2023.103545
Keywords
Port-wine stain; Hemoporfin-PDT; Multicenter study; Large-scale samples; Efficacy; Safety
Categories
Ask authors/readers for more resources
This study evaluated the efficacy and safety of Hemoporfin-mediated photodynamic therapy (Hemoporfin-PDT) for port-wine stain (PWS) in a real-life setting and investigated factors that influence the efficacy. A total of 1679 patients were included in the study. The response rate of purple-type PWS was significantly lower than that of pink-type PWS, and the response rate was lower in male patients with an age > 3 years or <= 6 years. Hemoporfin-PDT was well tolerated.
Background: Hemoporfin-mediated photodynamic therapy (Hemoporfin-PDT) has been approved for port-wine stain (PWS) in China in 2017. This study evaluated the efficacy and safety of Hemoporfin-PDT for PWS in a real life setting and investigated factors that influence the efficacy.Methods: A multicenter retrospective study included patients with PWS who underwent Hemoporfin-PDT in 29 hospitals across China and completed at least two months of follow-up. The efficacy was evaluated based on patien photographs.Results: A total of 1679 patients were included. After the first and second sessions of Hemoporfin-PDT, 63.5 and 75.3% of patients responded, respectively. The response rate of purple-type PWS was significantly lower than that of pink-type PWS (OR: 0.71, 95% CI: 0.54-0.94, P < 0.05), and there was no significant difference between thick-and pink-type (OR: 0.72, 95% CI: 0.42-1.22, P > 0.05). The response rate of PWS on the limbs was significantly lower than that on the mid-face (OR: 0.35, 95% CI: 0.23-0.53, P < 0.0001), while no significant difference was observed between PWS on the peripheral part of the face, neck or other parts of the body and PWS on the mid-face (P > 0.05). The response rate was lower in male patients with an age > 3 years or <= 6 years (P < 0.05). Previous treatment history did not affect the efficacy (P > 0.05). Hemoporfin-PDT was well tolerated.Conclusion: Patients with PWS have a good response and good tolerance to Hemoporfin-PDT.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available