Pathologic complete response after photodynamic therapy combined with dose-reduction chemoradiotherapy in elderly patient with severe obstruction esophageal carcinoma: A case report

Article Gastroenterology & Hepatology

Efficacy and safety of second photodynamic therapy for local failure after salvage photodynamic therapy for esophageal cancer

Hiroki Yamashita et al.

Summary: Second PDT showed good safety and acceptable efficacy in treating local failure after chemoradiotherapy for ESCC, indicating its potential as a treatment option for local recurrence after initial PDT.

DIGESTIVE ENDOSCOPY (2022)

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Article Surgery

Treatment strategies and outcomes for elderly patients with locally advanced squamous cell carcinoma of the esophagus

Ryotaro Kozuki et al.

Summary: There are significant differences in treatment strategies between elderly and younger patients with locally advanced esophageal squamous cell carcinoma (ESCC), with elderly patients having lower survival rates after surgery compared to younger patients.

SURGERY TODAY (2022)

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Article Gastroenterology & Hepatology

Association of local complete response with prognosis after salvage photodynamic therapy for esophageal squamous cell carcinoma

Yusuke Amanuma et al.

Summary: Photodynamic therapy (PDT) is an effective salvage endoscopic treatment for local failure after chemoradiotherapy (CRT) in esophageal cancer patients. Achieving local complete response by salvage PDT is associated with good prognosis in terms of overall survival and progression-free survival rates. This study provides insights into the potential benefits of salvage PDT for esophageal cancer patients with local failure after CRT.

DIGESTIVE ENDOSCOPY (2021)

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Article Oncology

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Hyuna Sung et al.

Summary: The global cancer burden in 2020 saw an estimated 19.3 million new cancer cases and almost 10.0 million cancer deaths. Female breast cancer surpassed lung cancer as the most commonly diagnosed cancer, while lung cancer remained the leading cause of cancer death. These trends are expected to rise in 2040, with transitioning countries experiencing a larger increase compared to transitioned countries due to demographic changes and risk factors associated with globalization and a growing economy. Efforts to improve cancer prevention measures and provision of cancer care in transitioning countries will be crucial for global cancer control.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

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Article Oncology

Esophageal cancer: trends in incidence and mortality in China from 2005 to 2015

Feifan He et al.

Summary: From 2005 to 2015, the incidence and mortality rates of esophageal cancer in China have declined, with higher rates in men and rural areas.

CANCER MEDICINE (2021)

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Article Gastroenterology & Hepatology

Esophageal stenting for benign and malignant disease: European Society of Gastrointestinal Endoscopy (ESGE) Guideline - Update 2021

Manon C. W. Spaander et al.

ENDOSCOPY (2021)

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Article Surgery

Morbidity and Mortality of Patients Who Underwent Minimally Invasive Esophagectomy After Neoadjuvant Chemoradiotherapy vs Neoadjuvant Chemotherapy for Locally Advanced Esophageal Squamous Cell Carcinoma A Randomized Clinical Trial

Hao Wang et al.

Summary: The study compared the safety and long-term survival outcomes of neoadjuvant chemoradiotherapy (nCRT) followed by minimally invasive esophagectomy (MIE) with neoadjuvant chemotherapy (nCT) followed by MIE for locally advanced esophageal squamous cell carcinoma (ESCC) patients. The initial results showed that nCRT followed by MIE had similar safety and better pathologic outcomes compared to nCT followed by MIE for treating locally advanced ESCC.

JAMA SURGERY (2021)

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Review Oncology

Esophageal Cancer in Elderly Patients, Current Treatment Options and Outcomes; A Systematic Review and Pooled Analysis

Styliani Mantziari et al.

Summary: For elderly patients with esophageal cancer, surgery combined with perioperative chemo- or chemoradiation offers the best chance for survival, despite the risk of higher complications. The quality of life after treatment is usually not compromised in elderly patients, but they face a higher risk of loss of autonomy. Based on the available data, excluding elderly patients from curative treatment solely based on age is not supported.

CANCERS (2021)

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Review Medicine, General & Internal

Clinical Practice of Photodynamic Therapy Using Talaporfin Sodium for Esophageal Cancer

Tomonori Yano et al.

Summary: Photodynamic therapy using a conventional photosensitizer was replaced by second-generation photosensitizer talaporfin sodium to reduce adverse reactions in treating esophageal cancer. Endoscopic PDT using talaporfin sodium was approved as a salvage treatment for patients with local failure after chemoradiotherapy for esophageal cancer, based on favorable clinical trial results. Further evaluation is needed to determine the importance of PDT in the treatment of esophageal cancer.

JOURNAL OF CLINICAL MEDICINE (2021)

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Article Oncology