4.5 Article

Male and female C57BL/6 mice display drug-induced aversion and reward in the combined conditioned taste avoidance/conditioned place preference procedure

Related references

Note: Only part of the references are listed.
Article Neurosciences

Effects of Methylone Pre-Exposure on Fluoxetine-Induced Conditioned Taste Avoidance in Male and Female Sprague-Dawley Rats

Hayley N. Manke et al.

Summary: Previous studies have found that the aversive effects of a drug are weakened when the pre-exposure and conditioning drugs are the same or different. Cross-drug pre-exposure, which involves different drugs, has been used to assess the mechanisms underlying drug aversive effects. This study examined the impact of methylone pre-exposure on taste avoidance induced by the serotonin reuptake inhibitor fluoxetine.

BRAIN SCIENCES (2023)

Review Clinical Neurology

Impact of the Aversive Effects of Drugs on Their Use and Abuse

Anthony L. Riley et al.

Summary: Drug use and abuse are complex issues with different determinants and consequences. The transition from impulsive to compulsive drug-taking is influenced by neuroadaptations in the brain. Reinforcement plays a role in drug intake, but drugs of abuse also have aversive effects that limit their intake. The aversive effects of drugs can be affected by various factors and have an impact on their use and abuse potential.

BEHAVIOURAL NEUROLOGY (2022)

Article Behavioral Sciences

Methylone pre-exposure differentially impacts the aversive effects of MDPV and MDMA in male and female Sprague-Dawley rats: Implications for abuse vulnerability

Hayley N. Manke et al.

Summary: This study investigates the impact of pre-exposure to the synthetic cathinone methylone on the aversive effects of MDPV and MDMA. The results suggest that pre-exposure to methylone can attenuate the aversive effects of MDPV and MDMA, with the attenuation being greater for MDPV and only observed in males for MDMA. These findings have implications for understanding and preventing polydrug use involving synthetic cathinones.

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR (2022)

Article Behavioral Sciences

Conditioned place preference for cocaine and methylphenidate in female mice from lines selectively bred for high voluntary wheel-running behavior

Margaret P. Schmill et al.

Summary: Using a unique mouse genetic model, the study found that selective breeding for increased voluntary running has modified the reward circuit in the brain, increasing motivation for running without affecting cocaine or methylphenidate reward. Both High Runner and control mice displayed significant conditioned place preference for cocaine and methylphenidate, with no statistical difference between the linetypes for either drug.

GENES BRAIN AND BEHAVIOR (2021)

Article Neurosciences

Examination of neuroinflammatory cytokine interleukin-1 beta expression in the medial prefrontal cortex, amygdala, and hippocampus for the paradoxical effects of reward and aversion induced by morphine

Ying-Chou Wang et al.

Summary: Evidence shows that abused drugs can induce both reward and aversion concurrently, involving the mPFC, amygdala, and hippocampus. After morphine administration, neuroinflammatory changes were observed in the mPFC, amygdala, and hippocampus, suggesting a connection between neuroinflammation and morphine addiction.

NEUROSCIENCE LETTERS (2021)

Article Neurosciences

Assessment of aversive effects of methylone in male and female Sprague-Dawley rats: Conditioned taste avoidance, body temperature and activity/stereotypies

Hayley N. Manke et al.

Summary: The study found that methylone induces taste avoidance, changes in temperature, and increased activity levels and stereotypies in rats, with both males and females showing similar responses but differing in general activity. While sex was not a significant factor in taste avoidance and temperature, differences were observed in activity levels and stereotypies between males and females. Further research on the impact of sex on the effects of methylone is necessary to fully understand the basis of these differences.

NEUROTOXICOLOGY AND TERATOLOGY (2021)

Article Medicine, General & Internal

The Paradoxical Effect Hypothesis of Abused Drugs in a Rat Model of Chronic Morphine Administration

Yinghao Yu et al.

Summary: Studies have shown that morphine can induce both reward and aversion effects simultaneously. A dose of 10mg/kg morphine only produces aversive conditioned taste aversion, leading to higher plasma CORT levels associated with stress. The aversion induced by morphine is likely stress-related and not a rewarding property of the drug.

JOURNAL OF CLINICAL MEDICINE (2021)

Article Substance Abuse

Cardiovascular effects of 3,4-methylenedioxypyrovalerone (MDPV) in male and female Sprague-Dawley rats

Samantha J. McClenahan et al.

DRUG AND ALCOHOL DEPENDENCE (2019)

Article Neurosciences

Ethanol Conditioned Taste Aversion in High Drinking in the Dark Mice

John C. Crabbe et al.

BRAIN SCIENCES (2019)

Article Neurosciences

Heroin-induced suppression of saccharin intake in OPRM1 A118G mice

Christopher S. Freet et al.

BRAIN RESEARCH BULLETIN (2018)

Article Psychology, Biological

Sex as a biological variable: Drug use and abuse

Anthony L. Riley et al.

PHYSIOLOGY & BEHAVIOR (2018)

Review Behavioral Sciences

Sex differences and the effects of estradiol on striatal function

John Meitzen et al.

CURRENT OPINION IN BEHAVIORAL SCIENCES (2018)

Review Neurosciences

Sex Differences, Gender and Addiction

Jill B. Becker et al.

JOURNAL OF NEUROSCIENCE RESEARCH (2017)

Article Neurosciences

Pharmacokinetic Profiles and Pharmacodynamic Effects for Methylone and Its Metabolites in Rats

Joshua S. Elmore et al.

NEUROPSYCHOPHARMACOLOGY (2017)

Review Biochemistry & Molecular Biology

Considering sex as a biological variable in preclinical research

Leah R. Miller et al.

FASEB JOURNAL (2017)

Article Behavioral Sciences

An assessment of sex differences in Δ9-tetrahydrocannabinol (THC) taste and place conditioning

Briana J. Hempel et al.

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR (2017)

Article Substance Abuse

The pharmacokinetics of racemic MDPV and its (R) and (S) enantiomers in female and male rats

Michael D. Hambuchen et al.

DRUG AND ALCOHOL DEPENDENCE (2017)

Article Developmental Biology

Age Differences in Conditioned Place Preferences and Taste Aversions to Nicotine

Carol A. Dannenhoffer et al.

DEVELOPMENTAL PSYCHOBIOLOGY (2016)

Article Neurosciences

Pharmacological effects of methamphetamine and alpha-PVP vapor and injection

Julie A. Marusich et al.

NEUROTOXICOLOGY (2016)

Article Behavioral Sciences

Sex differences in responsiveness to the prescription opioid oxycodone in mice

Devon Collins et al.

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR (2016)

Article Behavioral Sciences

Measures of the aversive effects of drugs: A comparison of conditioned taste and place aversions

Jonathan K. Gore-Langton et al.

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR (2015)

Article Behavioral Sciences

Sex differences in 3,4-methylenedioxypyrovalerone (MDPV)-induced taste avoidance and place preferences

Heather E. King et al.

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR (2015)

Article Pharmacology & Pharmacy

Mephedrone, Methylone and 3,4-Methylenedioxypyrovalerone (MDPV) Induce Conditioned Place Preference in Mice

Louise Karlsson et al.

BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY (2014)

Article Behavioral Sciences

Conditioned taste aversion to ethanol in a social context: Impact of age and sex

Melissa Morales et al.

BEHAVIOURAL BRAIN RESEARCH (2014)

Article Pharmacology & Pharmacy

Pharmacological characterization of designer cathinones in vitro

L. D. Simmler et al.

BRITISH JOURNAL OF PHARMACOLOGY (2013)

Article Clinical Neurology

An integrated pharmacokinetic and pharmacodynamic study of a new drug of abuse, methylone, a synthetic cathinone sold as bath salts

Raul Lopez-Arnau et al.

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY (2013)

Article Pharmacology & Pharmacy

Comparative neuropharmacology of three psychostimulant cathinone derivatives: butylone, mephedrone and methylone

Raul Lopez-Arnau et al.

BRITISH JOURNAL OF PHARMACOLOGY (2012)

Review Behavioral Sciences

Do initial responses to drugs predict future use or abuse?

Harriet de Wit et al.

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS (2012)

Article Neurosciences

Rewarding and aversive effects of nicotine are segregated within the nucleus accumbens

Laurie H. L. Sellings et al.

EUROPEAN JOURNAL OF NEUROSCIENCE (2008)

Review Biochemistry & Molecular Biology

Measuring reward with the conditioned place preference (CPP) paradigm: update of the last decade

Thomas M. Tzschentke

ADDICTION BIOLOGY (2007)

Article Multidisciplinary Sciences

Abolished cocaine reward in mice with a cocaine-insensitive dopamine transporter

Rong Chen et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)

Article Geriatrics & Gerontology

Impaired conditioned taste aversion learning in APP transgenic mice

C Janus et al.

NEUROBIOLOGY OF AGING (2004)

Article Neurosciences

Sex differences in the conditioned rewarding effects of cocaine

SJ Russo et al.

BRAIN RESEARCH (2003)

Article Neurosciences

Motivational effects of ethanol in DARPP-32 knock-out mice

FO Risinger et al.

JOURNAL OF NEUROSCIENCE (2001)

Article Behavioral Sciences

Ethanol-conditioned place preference is reduced in dopamine D2 receptor-deficient mice

CL Cunningham et al.

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR (2000)

Article Behavioral Sciences

Ethanol-induced conditioned place aversion in mice

CL Cunningham et al.

BEHAVIOURAL PHARMACOLOGY (2000)

Article Behavioral Sciences

DBA/2J mice develop stronger lithium chloride-induced conditioned taste and place aversions than C57BL/6J mice

FO Risinger et al.

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR (2000)