Antituberculotic Activity of 5-Aryl(Hetaryl)-Methylidene-2,4,6-Pyrimidine-2,4,6(1H,3H,5H)-Triones and 5-(2-Chloropropylidene)-2,4,6-Pyrimidine-2,4,6(1H,3H,5H)-Triones

The effect of 5-aryl(hetaryl)methylidene-2,4,6-pyrimidine-2,4,6(1H,3H,5H)-triones and 5-(2-chloropropylidene)-2,4,6-pyrimidine-2,4,6(1H,3H,5H)-triones on the viability of laboratory strain M. tuberculosis H(37)Rv was studied. The minimum inhibitory and bactericidal concentrations and the acute toxicity in mice have been determined. Compounds XIII, XIV, XVII, and XIX had the greatest antituberculotic activity for M. tuberculosis H(37)Rv, indicating they were promising for further studies aimed at creating effective antituberculotic drugs.

Automated summary

The effect of 5-aryl(hetaryl)methylidene-2,4,6-pyrimidine-2,4,6(1H,3H,5H)-triones and 5-(2-chloropropylidene)-2,4,6-pyrimidine-2,4,6(1H,3H,5H)-triones on the viability of M. tuberculosis H(37)Rv strain was investigated. Minimum inhibitory and bactericidal concentrations, as well as acute toxicity in mice, were determined. Compounds XIII, XIV, XVII, and XIX exhibited the strongest antituberculotic activity against M. tuberculosis H(37)Rv, suggesting their potential for further development as effective antituberculotic drugs.