Lucialdehyde B suppresses proliferation and induces mitochondria-dependent apoptosis in nasopharyngeal carcinoma CNE2 cells

Article Chemistry, Medicinal

Capilliposide from Lysimachia capillipes promotes terminal differentiations and reverses paclitaxel resistance in A2780T cells of human ovarian cancer by regulating Fos/Jun pathway

Ke Zhang et al.

Summary: This study found that Lysimachia capillipes capilliposide (LCC) can promote terminal differentiation of ovarian cancer cells and increase their sensitivity to paclitaxel, making it a potential novel therapy targeting cancer stem cells.

CHINESE HERBAL MEDICINES (2022)

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Article Biochemistry & Molecular Biology

Isolated Components From Spider Venom Targeting Human Glioblastoma Cells and Its Potential Combined Therapy With Rapamycin

Marcus Caballero et al.

Summary: Glioblastomas, a type of brain tumor, have a high mortality rate and pose challenges in therapy and prognosis. Peptide-based antineoplastic therapy using spider venom shows promise. This study explores the cytotoxic effects of Phoneutria nigriventer spider venom (PnV) on glioblastoma cells and identifies potential antineoplastic components. These components, particularly SF3 and SF4, show significant effects and may serve as prototypes for developing new drugs for glioblastoma treatment.

FRONTIERS IN MOLECULAR BIOSCIENCES (2022)

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Review Oncology

Targeting Ras-ERK cascade by bioactive natural products for potential treatment of cancer: an updated overview

Eunus S. Ali et al.

Summary: The MAPK pathway plays a crucial role in transmitting signals from outside the cell to inside, and is associated with cancer treatment response, normal cell pathway maintenance, and compensatory pathway activation. MAPK inhibitors often activate compensatory feedback loops, leading to resistance in tumor cells and microenvironment. Therefore, innovative combination therapies are needed to limit alternate pathway initiation.

CANCER CELL INTERNATIONAL (2022)

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Article Chemistry, Medicinal

Total flavonoids from the dried root of Tetrastigma hemsleyanum Diels et Gilg inhibit colorectal cancer growth through PI3K/AKT/mTOR signaling pathway

Yufei Zhai et al.

Summary: THTF could inhibit the growth of colorectal cancer cells and promote apoptosis, as well as delay the growth of xenografts. Its mechanism of action involves the inhibition of the PI3K/AKT/mTOR pathway.

PHYTOTHERAPY RESEARCH (2022)

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Review Plant Sciences

The signaling pathways and targets of traditional Chinese medicine and natural medicine in triple-negative breast cancer

Zimei Yang et al.

Summary: This review summarizes the mechanisms and clinical efficacy of traditional Chinese medicine and natural medicine in the treatment of triple-negative breast cancer. Evidence shows that their anti-tumor activity targets multiple pathways, providing a basis for new drug development and the need for further experimental research to enhance their clinical application.

JOURNAL OF ETHNOPHARMACOLOGY (2021)

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Article Oncology

Carnosic Acid Suppresses the Development of Oral Squamous Cell Carcinoma via Mitochondrial-Mediated Apoptosis

Fenghe Min et al.

Summary: The study showed that CA can inhibit cell proliferation and migration, promote cell apoptosis, and suppress oral squamous cell carcinoma (OSCC) development through the mitochondrial apoptotic pathway by regulating the expression of Bax, Bad, cleaved Caspase-3 and -9, PARP1, and Bcl-2.

FRONTIERS IN ONCOLOGY (2021)

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Review Chemistry, Medicinal

Ganoderma lucidum (Reishi) an edible mushroom; a comprehensive and critical review of its nutritional, cosmeceutical, mycochemical, pharmacological, clinical, and toxicological properties

Rizwan Ahmad et al.

Summary: Reishi mushroom has exceptional value in nutrition, cosmeceuticals, and medical treatments, but there is a lack of quality clinical data to support its pharmacological activities for human use. While Reishi shows promising pharmacological potential, further clinical studies are needed to validate its safety and efficacy.

PHYTOTHERAPY RESEARCH (2021)

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Article Pharmacology & Pharmacy

Combining Sodium Butyrate With Cisplatin Increases the Apoptosis of Gastric Cancer In Vivo and In Vitro via the Mitochondrial Apoptosis Pathway

Yangbo Li et al.

Summary: The combination of sodium butyrate and cisplatin increased apoptosis of GC cells and effectively inhibited tumor growth in a nude mouse xenograft tumor model. This combination also elevated intracellular ROS, reduced MMP, and suppressed invasion and migration abilities of GC cells. Western blotting confirmed enhanced levels of mitochondrial apoptosis-related pathway proteins.

FRONTIERS IN PHARMACOLOGY (2021)

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Review Oncology

Current Status and Future Perspectives about Molecular Biomarkers of Nasopharyngeal Carcinoma

Pui Yan Siak et al.

Summary: Nasopharyngeal carcinoma is a major public health problem in certain countries, particularly in Southern China and Southeast Asia, due to multifactorial interactions such as Epstein-Barr virus infection, genetic susceptibility, and environmental factors. Early diagnosis and reliable biomarkers are urgently needed for better management of NPC, as late presentation and complexity of the disease lead to high mortality rates. Understanding candidate biomarkers that promote NPC development and progression is crucial for the discovery of specific biomarkers for accurate diagnosis and targeted therapeutic development.

CANCERS (2021)

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Article Oncology